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Comparative pharmacokinetic evaluation of metronidazole in sheep and goats.
Res Vet Sci
December 2024
Department of Veterinary Sciences, University of Pisa, Viale delle Piagge, 2, 56124 Pisa, Italy; Department of Veterinary Sciences, University of Sassari, Via Vienna, 2, 07100 Sassari, Italy. Electronic address:
Metronidazole (MTZ) is a 5-nitroimidazole compound recognized for its dual anti-bacterial and anti-protozoal properties. Non-approved in many countries for farm medicine, due to a lack of data in the literature, the study aimed to determine its pharmacokinetics (PK) in sheep and goats following intravenous (IV) and subcutaneous (SC) administrations. Sheep (n = 5) and goats (n = 5) followed identical study protocols, which involved a two-phase, single-dose (2 mg/kg), cross-over study design with a one-week washout period between treatments.
View Article and Find Full Text PDFEvaluation of methotrexate Pharmacogenomic variation to predict acute neurotoxicity in children with acute lymphoblastic leukemia.
Pharmacotherapy
December 2024
Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.
Background: Methotrexate is an important component of curative therapy in childhood acute lymphoblastic leukemia (ALL), but the role of genetic variation influencing methotrexate clearance and transport in toxicity susceptibility in children with ALL is not well established. Therefore, we evaluated the association between suspected methotrexate pharmacogenomic variants and methotrexate-related neurotoxicity.
Methods: This study included children (aged 2-20 years) diagnosed with ALL (2005-2019) at six treatment centers in the southwest United States.
Resazurin dye is an in vivo sensor of kidney tubular function.
Kidney Int
December 2024
Division of Pharmaceutics and Pharmacology, College of Pharmacy & Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA. Electronic address:
Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.
View Article and Find Full Text PDFParaoxonase 1 ameliorates neurological symptoms and motor coordination impairment caused by cerebral ischemia-reperfusion injury.
Biomed Pharmacother
December 2024
Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama-shi, Kanagawa 227-0033, Japan. Electronic address:
Article Synopsis
- HDL (high-density lipoprotein) has protective effects against cerebral infarction due to its antioxidant, anti-inflammatory, and antithrombotic properties, but there's a lack of effective clinical treatments.
- Researchers focused on paraoxonase 1 (PON1), an enzyme linked to HDL, to develop it as a new therapy for ischemia-reperfusion injury in stroke.
- The study found that PON1 can effectively bind to HDL, reduce infarct volume in a mouse model, and improve neurological function, suggesting its potential as a treatment for acute stroke.
Immune deficiency phenotypes of Il2rg, Rag2 or Il2rg/Rag2 double knockout rats; establishment of human leukemia xenograft models.
Lab Anim Res
December 2024
Department of Experimental Animal Research, Biomedical Research Institute, Seoul National Univ. Hospital, Seoul, Korea.
Background: Genetically immunodeficient mice lacking Il2rg and Rag2 genes have been widely utilized in the field of biomedical research. However, immunodeficient rats, which offer the advantage of larger size, have not been as extensively used to date. Recently, Severe Combined Immunodeficiency (SCID) rats were generated using CRISPR/Cas9 system, targeting Il2rg and Rag2 in National BioResource Project in Japan.
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