Purpose: Resveratrol, a phytochemical known for its anti- oxidative properties has been explored worldwide for anticancer potential. We performed this systematic review and meta-analysis in order to register the efficacy of resveratrol against lung carcinogenesis.
Methods: We searched PubMed for preclinical studies reporting efficacy of resveratrol alone or in combination with drugs like curcumin, cisplatin etc. against lung carcinogenesis.
Results: The primary outcome of eligible studies included change in overall tumor incidence as well as tumor size. In all of the above studies involving either animal models or in vitro cancer cell experiments a statistically significant reduction in tumor incidence emerged as compared with the control groups, yielding a relative risk reduction of 0.64 (p=0.002). This meta- analysis confirmed the potential of resveratrol against lung carcinogenesis.
Conclusion: It can be concluded that resveratrol holds a good potential for future use as a highly efficient therapeutic agent to deal with deadly lung carcinogenesis.
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Article Synopsis
- Resveratrol is a natural compound with anti-inflammatory and antioxidant properties that may delay cellular aging by affecting RNA m6A methylation, which is linked to oxidative stress and age-related disorders.
- The study used a model of premature senescence in human embryonic lung fibroblasts and found that resveratrol improved cell viability and reduced markers of senescence like SA-β-gal staining and ROS levels.
- It also increased the activity of RNA methyltransferases and m6A levels, identifying specific genes involved in its anti-aging effects, which provides new insights into how resveratrol could help combat premature aging.
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