In this study, the outcome of treatment with Flammacerium in burn patients is studied. The retrospective study involved patients with acute burns admitted to the Burn Centre of Martini Hospital, Groningen, The Netherlands, between 2009 and 2014. The outcome parameters were mortality, complications (noninfectious and infectious), need of surgery, and length of stay. The group of patients consisted of 853 patients, of which 554 were male (64.9%). There were 23 patients with a total burn size of 40% TBSA or more (2.7%). In total, 13 of the 853 patients (1.5%) died, and none of them were children (<16 years). The overall mortality in the group of patient with burns >40% TBSA was 30.4%. In the elderly group (>70 years), the mortality rate was 6.3%. Treatment with Flammacerium is applicable in all thermal burn patients. Especially children, elderly patients, and patients with severe burns can benefit from a more conservative treatment with Flammacerium whereby the first operation can be postponed until the patient is stabilized and in which the wounds can be covered directly with skin transplants.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/BCR.0000000000000448 | DOI Listing |
Antibiotics (Basel)
December 2024
Combat Wound Care Group, CRT 4, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
: Due to rising antibiotic-resistant microorganisms, there is a pressing need to screen approved drugs for repurposing and to develop new antibiotics for controlling infections. Current in vitro and ex vivo models have mostly been unsuccessful in establishing in vivo relevance. In this study, we developed a stringent ex vivo-burned porcine skin model with high in vivo relevance to screen topical antimicrobials.
View Article and Find Full Text PDFInt J Burns Trauma
October 2023
Department of Clinical Pharmacy, Mashhad University of Medical Sciences Mashhad, Iran.
Background: Burn injury is a major global health crisis. Topical antimicrobials such as silver sulfadiazine (SSD) are commonly used for superficial burn wounds. SSD has a broad-spectrum antimicrobial activity and also anti-inflammatory property, but also suffers from some limitations.
View Article and Find Full Text PDFMolecules
April 2022
Mechanisms of Health & Disease, School of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UK.
Cerium and its derivatives have been used as remedies for wounds since the early 20th century. Cerium nitrate has attracted most attention in the treatment of deep burns, followed later by reports of its antimicrobial properties. Its ability to mimic and replace calcium is presumed to be a major mechanism of its beneficial action.
View Article and Find Full Text PDFInt J Low Extrem Wounds
September 2018
1 Montpellier University Hospital, Montpellier, France.
Flammacerium is a topical treatment composed of silver sulfadiazine and cerium nitrate initially used in burns. The objective was to assess the effectiveness of silver sulfadiazine and cerium nitrate on ischemic necrosis wounds of the lower limb as an alternative to amputation for a period of 12 weeks. Patients were prospectively randomized to receive silver sulfadiazine and cerium nitrate or standard care.
View Article and Find Full Text PDFBurns
June 2017
Department of Surgery, Burn Center, Maasstad Hospital, Rotterdam, The Netherlands.
Aim: The aim of this study was to compare the clinical outcomes of different treatment strategies for children with partial-thickness scalds at two burn centers. At the first burn center, these burns were treated with a hydrofiber dressing (Aquacel, Convatec, Inc., Princeton, NJ, USA) or silver sulfadiazine (SSD, Flammazine, Sinclair IS Pharma, London, UK Pharmaceuticals), while at the second burn center, cerium nitrate-silver sulfadiazine (CN-SSD, Flammacerium, Sinclair IS Pharma, London, UK Pharmaceuticals) was used.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!