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Pulmonary thromboembolism in adults: Experience from a tertiary care center.
Med J Armed Forces India
December 2024
Resident (Pulmonary, Critical Care & Sleep Medicine), Army Institute of Cardio Thoracic Sciences (AICTS), Pune, India.
Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). We aimed to analyze the risk factors, clinical presentations, evaluation and management strategies as well as outcomes of adult pulmonary thromboembolism cases at a tertiary care center.
Methods: In a retrospective observational study, all consecutive adult pulmonary thromboembolism cases admitted from January 2019 to September 2020 at our center were enrolled in this study.
Weakness of left hand in a diagnosed case of pulmonary tuberculosis: A rare case of disseminated tuberculosis with wrist tenosynovitis.
Med J Armed Forces India
December 2024
Graded Specialist (Pulmonary & Sleep Medicine), Command Hospital (Northern Command), Udhampur, India.
Peripartum genital tuberculosis causing uterine scar dehiscence and secondary post-partum hemorrhage: Exceedingly rare yet alarmingly life threatening.
Med J Armed Forces India
December 2024
Professor (Obst & Gynae), All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Design, synthesis and biological evaluation of ethyl 5-(1-benzyl-1H-indol-5-yl)isoxazole-3-carboxylates as antimycobacterial agents.
ChemMedChem
December 2024
NIPER Hyderabad: National Institute of Pharmaceutical Education and Research Hyderabad, Chemical Sciences, Balanagar, 500037, Hyderabad, INDIA.
The continued prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains, particularly against first-line antitubercular (anti-TB) drugs, presents an impending public health threat that necessitates the exploration and development of New Chemical Entities (NCEs). In search of new anti-TB leads, a library of ethyl 5-(1-benzyl-1H-indol-5-yl)isoxazole-3-carboxylates were generated through a strategy of scaffold hopping from the proven isoxazole-3-carboxylate-based anti-TB pharmacophore. We evaluated their antibacterial potential against a panel of pathogenic bacteria and MtbH37Rv strains.
View Article and Find Full Text PDFTuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.
Drugs
December 2024
The Aurum Institute, Parktown, South Africa.
Tuberculosis (TB) is the leading cause of death from a single infectious agent. The burden is highest in some low- and middle-income countries. One-quarter of the world's population is estimated to have been infected with TB, which is the seedbed for progressing from TB infection to the deadly and contagious disease itself.
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