Animal experimentation is presented to the public as an ongoing debate between research scientists on one hand, and the animal protection community on the other. An opportunity to break out of this mindset presented itself in the form of a European Citizens' Initiative, Stop Vivisection, which challenged Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals for scientific purposes. The manifesto of the initiative called upon the European Commission to replace the existing Directive with a new proposal that does away with animal experimentation, and instead makes compulsory the use of human data as a predictive modality for the study of human diseases and responses to drugs. Although the Initiative succeeded in gathering the required one million signatures, the European Commission ultimately rejected the proposal. However, some of the lessons learned from the Initiative may well be relevant to the revision of Directive 2010/63/EU, due to take place by 2017.
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http://dx.doi.org/10.1177/026119291604400408 | DOI Listing |
PLoS One
January 2025
Department of Public Health, Healthcare Innovation & Evaluation and Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Objectives: Solidarity-based healthcare systems are being challenged by the incremental costs of new and expensive medicines for cancer and rare diseases. To regulate reimbursement of such drugs, the Dutch government introduced a policy instrument known as the Coverage Lock (CL) in 2015. Little is known about the public opinion regarding such policy instruments and their consequences, i.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Deustotech, University of Deusto, Avda. Universidades 24, 48007 Bilbao, Spain.
This work addresses the task allocation problem in spatial crowdsensing with altruistic participation, tackling challenges like declining engagement and user fatigue from task overload. Unlike typical models relying on financial incentives, this context requires alternative strategies to sustain participation. This paper presents a new solution, the Volunteer Task Allocation Engine (VTAE), to address these challenges.
View Article and Find Full Text PDFEnviron Pollut
January 2025
Centre for Environmental and Climate Science, Lund University, Sweden.
Urban environments are exposed to a substantial range of anthropic pressures, including chemical exposure. While trace metals and legacy pollutants have been well documented, the extent of wildlife exposure to emerging contaminants has received little attention, in terrestrial mammals. Concentrations of trace elements (Ag, Al, As, Cd, Co, Cr, Cu, Fe, Mn, Pb and Zn) and 48 organic pollutants (Polychlorinated Biphenyls: PCBs, Organochlorine Pesticides: OCPs, Polycyclic Aromatic Hydrocarbons: PAHs, phthalates and pyrethroid pesticides) were measured in tissues of European hedgehogs (Erinaceus europaeus) in southern Sweden.
View Article and Find Full Text PDFBackground: Belzutifan, a first-in-class HIF-2α inhibitor, has shown antitumour activity as monotherapy and in combination with cabozantinib in patients with previously treated advanced kidney cancer. The phase 2 LITESPARK-003 study was designed to determine the antitumour activity and safety of belzutifan in combination with cabozantinib in patients with advanced clear-cell renal cell carcinoma that was previously untreated (cohort 1) or previously treated with immunotherapy (cohort 2). Here, we report results from cohort 1 of this clinical trial.
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
Institute of Geography, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 04001, Košice, Slovak Republic.
In recent decades, global climate change and rapid urbanization have aggravated the urban heat island (UHI) effect, affecting the well-being of urban citizens. Although this significant phenomenon is more pronounced in larger metropolitan areas due to extensive impervious surfaces, small- and medium-sized cities also experience UHI effects, yet research on UHI in these cities is rare, emphasizing the importance of land surface temperature (LST) as a key parameter for studying UHI dynamics. Therefore, this paper focuses on the evaluation of LST and land cover (LC) changes in the city of Prešov, Slovakia, a typical medium-sized European city that has recently undergone significant LC changes.
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