Mixed adenoneuroendocrine carcinomas (MANECs) are composite neoplasms with areas of adenocarcinoma or squamous cell carcinoma intermingled with neuroendocrine carcinoma or neuroendocrine tumor, each composing at least 30% of the neoplasm. MANECs are very infrequent overall, and they are more commonly diagnosed in the appendix, colon, and stomach. Biliary MANECs are particularly rare, and their histogenesis is debated because neuroendocrine cells are seldom identified in the normal biliary tract. They can show one of the 3 different architectural patterns described in Lewin's original classification: collision tumors, combined lesions, or amphicrine neoplasms. The neuroendocrine component is usually of a high grade, with small or large cell cytomorphology, whereas the adenocarcinoma component is either an intestinal or biliary type. Clinical presentation is characterized by locally advanced disease at the time of initial diagnosis. Recent studies suggest that treatment should be guided by the most aggressive histologic component.
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Two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix: case report and review of the literature.
Diagn Pathol
December 2024
Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang Province, 321000, China.
Background: Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2 cases of MANEC of the cervix and discuss important considerations for diagnosing cervical poorly differentiated carcinoma.
Case Presentation: we reported two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, one HPV-independent and one HPV-associated, both with vaginal bleeding.
Successful conversion surgery after comprehensive therapy in a patient with MSI-H but pMMR metastatic gastric mixed adenoneuroendocrine carcinoma: a case report and literature review.
Front Oncol
December 2024
Department of Gastroenterology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a rare and highly aggressive malignancy characterized by both exocrine and neuroendocrine components. Treatment options for metastatic cases are limited, with typical therapeutic approaches involving a combination of chemotherapy and immunotherapy. A 68-year-old male with metastatic gastric MANEC was treated with targeted therapy, immunotherapy, and chemotherapy, including S-1, apatinib, cadonilimab, and paclitaxel.
View Article and Find Full Text PDFGastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult.
GE Port J Gastroenterol
December 2024
Department of Gastroenterology, Hospital de Braga, Braga, Portugal.
Article Synopsis
- Gastric cancer, primarily adenocarcinomas, is a leading cause of cancer death, and mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is one of the rarest subtypes, with significant bleeding occurring in some patients.
- A case study involves a healthy 26-year-old male who had two major gastrointestinal bleeding episodes, leading to the discovery of a 15-mm lesion at the gastroesophageal junction, which was later diagnosed as a mixed adenoneuroendocrine carcinoma.
- Despite its rarity and the lack of established treatment protocols, the patient underwent surgery and chemotherapy, with no evidence of cancer recurrence two years later.
[Neuroendocrine carcinomas of the gastrointestinal tract : Morphology, molecular pathology, cellular origin].
Pathologie (Heidelb)
November 2024
Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Gießen und Marburg, Standort Marburg, Marburg, Deutschland.
Neuroendocrine carcinomas (NEC) are poorly differentiated neuroendocrine neoplasms that can occur ubiquitously in the mucosa-bearing organs of the gastrointestinal tract. Based on their morphology, they are classified into large cell (LCNEC) and small cell NEC (SCNEC). The most common form of mixed differentiation is the combination with an adenocarcinoma, referred to as mixed adenoneuroendocrine carcinoma (MANEC).
View Article and Find Full Text PDFMixed adenoneuroendocrine carcinomas of the appendix: Is there a survival advantage to right hemicolectomy over appendectomy?
Eur J Surg Oncol
January 2025
Department of General Surgery, Huzhou Central Hospital (The Affiliated Central Hospital of Huzhou University, The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine), Huzhou, 313000, China. Electronic address:
Background: the surgical treatment and prognostic characteristics of mixed adenoneuroendocrine carcinomas (MANEC) of the appendix are not yet available. In this study, we sought to figure out the choice of surgical approach (right hemicolectomy versus appendectomy), and explore the effect of chemotherapy on appendiceal MANEC.
Methods: patients with appendiceal MANEC from the Surveillance, Epidemiology, and End Results database (2000-2020) were stratified by gender, race, age group, tumor grade, and TNM stage.
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