Turn up the lysosome. | LitMetric

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Turn up the lysosome. | LitMetric

Turn up the lysosome.

Paul Saftig Albert Haas

Nat Cell Biol

Institute for Cell Biology of the Rheinische Friedrich-Wilhelms University Bonn, D-53121 Bonn, Germany.

Published: September 2016

Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.

Download full-text PDF	Source
http://dx.doi.org/10.1038/ncb3409	DOI Listing

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