Nanotechnology involving manipulation of atoms and molecules at the nanoscale is one of the frontier areas of research in modern science. During the last few years, nanotechnology has witnessed breakthroughs in the fields of medicine, environment, therapeutics, drug development and biotechnology. This is due to the unique properties of nanomaterials (e.g. chemical, mechanical, optical, magnetic, and biological) which make them desirable for commercial and medical applications. Considering the theory and practice of using nanoparticles, nanotechnology has a great potential in improving treatment of various disorders and in vitro diagnostics. However, there is not much information available on the toxicity of nanoparticles in relation to human health. Toxic effect of nanomaterials on humans is the primary concern of the health industry. Nanomaterials are able to cross biological membranes and access cells, tissues and organs that larger-sized particles normally cannot. Nanomaterials can gain access to the blood stream via inhalation or ingestion. This may lead to both genotoxicity and biochemical toxicity. In this review we try to show which types, sizes and concentrations of nanoparticles are safe for human use and this will help in developing diagnostic, prognostic and therapeutic models using nanoparticles.
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