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Biotechnological progresses in modelling the human endometrium: the evolution of current techniques and emerging trends.
Front Bioeng Biotechnol
December 2024
IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.
The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman's syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devastating disorder. Appropriate model systems that closely mimic the architecture and function of the endometrium in healthy and pathological states are needed to understand the underlying molecular pathways and develop novel or more effective treatments.
View Article and Find Full Text PDFMechanistic insights into intrauterine adhesions.
Semin Immunopathol
November 2024
Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Article Synopsis
- Intrauterine adhesions (IUA), also known as Asherman's syndrome, occur due to damage to the endometrial layer, often from medical procedures, leading to fibrous tissue formation that can block the uterine cavity or cervical canal.
- Diagnosis of IUA is best performed through hysteroscopy, but predicting future live birth rates remains uncertain.
- New research on the underlying causes of IUA, including inflammation, cellular balance issues, autophagy defects, and ferroptosis, is essential for developing improved treatment strategies.
Application of Additive Manufacturing in Assisted Reproductive Techniques: What Is the Evidence? A Clinical and Technical Systematic Review of the Literature.
Medicina (Kaunas)
November 2024
Medical School, National and Kapodistrian University of Atehns, 115 27 Athens, Greece.
This article investigates the transformative impact of 3D and bio 3D printing technologies in assisted reproductive technology (ART), offering a comprehensive review of their applications in improving reproductive outcomes. Following PRISMA guidelines, we conducted a thorough literature search focusing on the intersection of ART and additive manufacturing, resulting in the inclusion of 48 research papers. The study highlights bio 3D printing's potential in revolutionizing female infertility treatments, especially in follicle complex culture and ovary printing.
View Article and Find Full Text PDFSpontaneous Uterine Rupture in Pregnancy After Treatment of Asherman Syndrome.
J Minim Invasive Gynecol
November 2024
Spaarne Gasthuis, Department of Obstetrics and Gynecology (Bos, Vollebregt, and Hanstede), Haarlem, The Netherlands; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht (Hanstede), Utrecht, The Netherlands.
Study Objective: Women with Asherman syndrome are at high risk of recurrent adhesions and pregnancy complications. Spontaneous uterine rupture is a rare but life-threatening complication, associated with severe maternal and fetal morbidity and mortality. Uterine ruptures can occur after extended induction of labor or a history of cesarean section, whereas spontaneous uterine rupture in an unscarred uterus is rare.
View Article and Find Full Text PDFAdvances in Mesenchymal Stem Cell Research Applications for Female Infertility-Mechanisms, Efficacy Parameters, Challenges and Future Roadmap.
Galen Med J
October 2024
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Infertility affects approximately 15-20% of couples globally, with female factors contributing to nearly half of cases. Conditions such as polycystic ovary syndrome, endometriosis, tubal damage and premature ovarian failure are leading causes of female infertility. Current treatments like in vitro fertilization (IVF) have limitations and risks.
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