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Prediction of Central Post-Stroke Pain by Quantitative Sensory Testing.
Ann Neurol
December 2024
Department of Neurology, Jewish Hospital Berlin, Berlin, Germany.
Objective: Among patients with acute stroke, we aimed to identify those who will later develop central post-stroke pain (CPSP) versus those who will not (non-pain sensory stroke [NPSS]) by assessing potential differences in somatosensory profile patterns and evaluating their potential as predictors of CPSP.
Methods: In a prospective longitudinal study on 75 acute stroke patients with somatosensory symptoms, we performed quantitative somatosensory testing (QST) in the acute/subacute phase (within 10 days) and on follow-up visits for 12 months. Based on previous QST studies, we hypothesized that QST values of cold detection threshold (CDT) and dynamic mechanical allodynia (DMA) would differ between CPSP and NPSS patients before the onset of pain.
Revisiting negative pressure wound therapy from a mechanobiological perspective supported by clinical and pathological data.
Int Wound J
December 2024
Wound Care Centre (Centro Aziendale di Riparazione Tissutale), Castellammare di Stabia, Italy.
Negative pressure wound therapy is used often in the management of surgical incisions, chronic wounds and subacute lesions, and there are numerous publications discussing its clinical application and outcomes. However, whilst clinical use and associated literature have expanded since these systems became commercially available in the 90s, important research and discussion around the mode of action have waned, leading to a deficit in the understanding of how this important therapy influences healing. Further, much research and many publications are predominantly reflective, discussing early theorem, some of which have been proven incorrect, or at least not fully resolved leading to misunderstandings as to how the therapy works, thus potentially denying the clinician the opportunity to optimise use towards improved clinical and economic outcomes.
View Article and Find Full Text PDFMechanically assisted walking with body weight support results in more independent walking and better walking ability compared with usual walking training in non-ambulatory adults early after stroke: a systematic review.
J Physiother
January 2025
Department of Physiotherapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Questions: In subacute, non-ambulatory individuals after stroke, does mechanically assisted walking with body weight support result in more independent walking or better walking ability than usual walking training in the short term? Are any benefits maintained in the longer term? Is it detrimental to walking in terms of walking speed?
Design: A systematic review with meta-analysis of randomised studies with a Physiotherapy Evidence Database (PEDro) score > 4.
Participants: Non-ambulatory adults ≤ 12 weeks after stroke.
Intervention: Any type of mechanically assisted walking with body weight support.
Subacute Stent Thrombosis Related to Kounis Syndrome During Anaphylaxis Induced by Ultrasound Contrast Agent Infusion.
JACC Case Rep
November 2024
Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Article Synopsis
- A 44-year-old man experienced a severe allergic reaction after receiving SonoVue during a heart test, leading to chest pain and a heart attack caused by stent thrombosis and coronary vasospasm.
- Treatment involved mechanical thrombectomy, stent replacement, and careful management to avoid worsening the patient's condition, ultimately resulting in his recovery and discharge with normal heart function.
Approachability and Sensory Changes Following Mild Traumatic Brain Injury in Pigs.
Biomedicines
October 2024
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298-0709, USA.
Background/objectives: Traumatic brain injury (TBI) is a global healthcare concern affecting millions, with wide-ranging symptoms including sensory and behavioral changes that can persist long-term. Due to similarities with human brain cytoarchitecture and inflammation, minipig models are advantageous for translational TBI research. However, gaps in knowledge exist regarding their behavioral and sensory sequelae following injury.
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