Aim: To examine the clinical and radiographic appearance of teeth with immature apices that were treated by single step procedure using mineral trioxide aggregate (MTA).
Summary: Creation of a physiological hard tissue barrier with calcium hydroxide in a nonvital tooth although quite predictable has certain limitations, such as the very long duration of the treatment spread over multiple visits and increased risk of root fracture. Plugging the root canal end with MTA has been advocated as an alternative treatment modality for open apices. The technique has been proven to be successful in many recently reported cases. The cases reported here present the successful treatment of two traumatized maxillary central incisors with open apices and periapical lesions using MTA. In this case report, MTA has been used to create a hard tissue barrier after disinfection of the root canal.
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http://dx.doi.org/10.5005/jp-journals-10005-1122 | DOI Listing |
ACS Nano
January 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore.
The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations of monotherapy and augment therapeutic efficacy. However, it remains a challenge to design a single delivery vehicle that can incorporate chemotherapeutics and radionuclides into a compact structure. Here, a chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble into nanoparticles due to its inherent amphiphilicity.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Nanjing University, School of Chemistry and Chemical Engineering, CHINA.
Proximity labeling (PL) has emerged as a powerful technique for the in situ elucidation of biomolecular interaction networks. However, PL methods generally rely on single-biological-hierarchy control of spatial localization at the labeling site, which limits their application in multi-tiered biological systems. Here, we introduced another enzymatic reaction upstream of an enzyme-based PL reaction and targeted the two enzymes to markers indicating different biological hierarchies, establishing a two-level spatially localized proximity labeling (P2L) platform for in situ molecular measurement and manipulation.
View Article and Find Full Text PDFNano Lett
January 2025
Department of Physics, Centre for Materials Science and Nanotechnology, University of Oslo, PO Box 1048 Blindern, N-0316 Oslo, Norway.
Polymorphism determines significant variations in materials' properties by lattice symmetry variation. If they are stacked together into multilayers, polymorphs may work as an alternative approach to the sequential deposition of layers with different chemical compositions. However, selective polymorph crystallization during conventional thin film synthesis is not trivial; changes of temperature or pressure when switching from one polymorph to another during synthesis may cause degradation of the structural quality.
View Article and Find Full Text PDFJ Exp Psychol Hum Percept Perform
January 2025
School of Psychology, University of Leeds.
Multi-item retro-cueing effects refer to better working memory performance for multiple items when they are cued after their offset compared to a neutral condition in which all items are cued. However, several studies have reported boundary conditions, and findings have also sometimes failed to replicate. We hypothesized that a strategy to focus on only one of the cued items could possibly yield these inconsistent patterns.
View Article and Find Full Text PDFMater Horiz
January 2025
Beijing Key Laboratory for Optical Materials and Photonic Devices, Department of Chemistry, Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing 100048, P. R. China.
Linearly-polarized organic electroluminescent devices have gained significant attention due to their potential applications across various fields. However, traditional thin-film organic light-emitting diodes (OLEDs) face significant challenges, primarily due to the necessity of incorporating complex optical elements. In this study, we present linearly-polarized OLEDs (LP-OLEDs) based on organic single crystals that we have designed and prepared.
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