AI Article Synopsis
- The study investigates the biosynthesis of gold nanoparticles (AuNPs) using a specific marine bacteria isolated from salt pan soils in Andhra Pradesh, India.
- The characterization of the AuNPs is conducted through various techniques, revealing that they are spherical with a size range of 12-20 nm and an average diameter of 14 nm.
- The AuNPs demonstrate significant anti-diabetic effects by inhibiting key enzymes and reducing blood glucose levels in diabetic rats, indicating their potential as a treatment for type II diabetes mellitus.
Article Abstract
The present study focuses on the biosynthesis of gold nanoparticles (AuNPs) using () SRBVIT13 isolated from marine salt pan soils collected from Ongole, Andhra Pradesh, India. The biosynthesised AuNPs are characterised by UV-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy and energy-dispersive X-ray analysis. Transmission electron microscopy study suggests that the biosynthesised AuNPs are spherical in shape within a size range of 12-20 nm (mean diameter as 14 nm). The anti-type II diabetes activity of AuNPs is carried out by testing it -glucosidase and -amylase enzyme inhibition activity and postprandial anti-hyperglycemic activity in sucrose and glucose-loaded streptozotocin induced diabetic albino Wister rats. AuNPs has shown a significant inhibitory activity of 84.70 and 87.82% with IC values of 67.65 and 65.59 μg/mL to -glucosidase and -amylase enzymes, while the diabetic rats have shown significant reduction in the post postprandial blood glucose level by 57.80 and 88.09%, respectively compared with control group after AuNPs treatment at the concentration of 300 and 600 mg/kg body weight. Hence, this biosynthesised AuNPs might be useful in combating type II diabetes mellitus for the betterment of human life.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8676180 | PMC |
| http://dx.doi.org/10.1049/iet-nbt.2015.0094 | DOI Listing |
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