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Reforming the innovation system to deliver affordable medicines: a conceptual framework of pharmaceutical innovation as a complex adaptive system (forest) and theory of change.
J Pharm Policy Pract
January 2025
Global Health Centre, Graduate Institute of International and Development Studies, Geneva, Switzerland.
Background: The current mainstream pharmaceutical innovation system (PIS) is driven by the market-based logic of charging the highest prices societies will bear. Outcomes include unaffordable medicines, restricted access and pressure on health budgets. How can the innovation system change to deliver fairly-priced medicines?
Methods: We inductively developed a novel conceptual framework of the PIS as a complex adaptive system (CAS) analogous to a forest.
Cost-Utility Analysis of Erenumab Compared to Topiramate for Preventive Therapy of Migraine in Iran.
Iran J Pharm Res
September 2024
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Background: Migraine is a prevalent, chronic neurovascular disorder that incurs significant indirect costs due to productivity loss. Preventive therapy is an effective way to alleviate the societal and healthcare burden of migraine. Approximately 14% of both the global and Iranian populations are affected by migraine, which has substantial economic implications.
View Article and Find Full Text PDFStars, stripes and scripts: Innovations and challenges in US pharmacy.
Future Healthc J
December 2024
OMS-IV at the West Virginia School of Osteopathic Medicine (WVSOM), 400 Lee St, Lewisburg, WV 24901, USA.
Pharmacy practice in the United States has evolved, transitioning from simple dispensing to complex compounding and medication management. Pharmacists play important roles across many sectors, including clinical care, pharmaceutical industry, insurance companies, and public health. Pharmacists optimize therapy, improve patient outcomes, and reduce healthcare costs.
View Article and Find Full Text PDFHow Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study.
Drugs Aging
January 2025
Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: Preventive medications are potential targets for deprescribing in older adults with dementia as goals of care change from preventive to palliative. Yet, prescribers lack communication guidance to address deprescribing.
Objective: Using bisphosphonates as a case example, we sought to characterize and compare communication preferences of prescribers and family/informal caregivers regarding deprescribing.
Trends in anti-seizure medication spending by Medicare Part D and Medicaid from 2012 to 2022.
Epilepsy Behav
January 2025
Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:
Objectives: The rising cost of anti-seizure medications (ASMs) in the United States (US) is a major concern for patients, healthcare providers, insurance payors, and policymakers. We aim to describe and analyze the spending trends on ASMs in the Medicare Part D (MPD) and Medicaid population in the US.
Methods: A retrospective study was conducted on the databases of MPD and Medicaid Spending by Drug from 2012 to 2022, which was published by the Centers for Medicare and Medicaid Services (CMS).
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