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A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.
Diabetologia
November 2024
Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Article Synopsis
- Monogenic diabetes results from rare gene mutations affecting beta cell function, and this study examines how common variants may also influence young-onset type 2 diabetes (YOD) and related health issues.
- Researchers created a weighted polygenic risk score (wPRS) using data from individuals with and without YOD to explore the association of 135 common variants across 34 monogenic diabetes genes.
- The findings indicate that higher wPRS correlates with an increased likelihood of YOD and a higher risk for cardiovascular and kidney events in individuals with type 2 diabetes.
Listening to voices from multiple sources: A qualitative text analysis of the emotional experiences of women living with breast cancer in China.
Front Public Health
February 2023
Department of Nursing, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Receiving a breast cancer diagnosis and treatment is both a physical and emotional journey. Previous studies using single-source data have revealed common and culture-specific emotional experiences of patients living with breast cancer. However, few studies have combined such data from multiple sources.
View Article and Find Full Text PDFUnderdiagnosis, false diagnosis and treatment of COPD in a selected population in Northern Greece.
Eur J Gen Pract
December 2021
Pulmonary Department, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece.
Background: In the primary care setting, diagnosis and treatment of COPD is not always consistent with GOLD guidelines.
Objectives: To calculate the prevalence of COPD underdiagnosis, false diagnosis and treatment in the general population of northern Greece.
Methods: Observational study in the context of an early COPD detection and smoking cessation project.
Beyond the HIV Care Continuum and Viral Suppression: Broadening the Scope of Quality Metrics for Total HIV Patient Care.
AIDS Patient Care STDS
November 2020
Kaiser Permanente Northern California Division of Research, Oakland, California, USA.
Assessing quality care for people with HIV (PWH) should not be limited to reporting on HIV Care Continuum benchmarks, particularly viral suppression rates. At Kaiser Permanente Mid-Atlantic States (KPMAS), an integrated health system providing HIV care in the District of Columbia, Maryland, and Virginia, we created a comprehensive measure of HIV quality care, including both preventative measures and clinical outcomes. We included PWH ≥18 years old with ≥6 months KPMAS membership between 2015 and 2018.
View Article and Find Full Text PDFBackground: Drugs for inflammatory conditions are one of the highest expenditure therapeutic classes for health plans. Published literature for adherence, persistence, nonadherence risk factors, and health care costs are incomplete for newer biologic agents.
Objectives: To (a) examine differences in adherence, persistence, switch patterns, and health care costs among high-cost specialty anti-inflammatory medications and (b) suggest risk factors for nonadherence in rheumatoid arthritis.
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