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Cediranib and Olaparib Combination Compared With Cediranib or Olaparib Alone, or Chemotherapy in Platinum-Resistant or Primary Platinum-Refractory Ovarian Cancer: NRG-GY005.
J Clin Oncol
December 2024
Gynecologic Oncology, Duke University Medical Center, Duke Cancer Institute, Durham, NC.
Purpose: We assessed the efficacy of cediranib, olaparib, and cediranib/olaparib compared with standard-of-care chemotherapy (SOC) in platinum-resistant or platinum-refractory epithelial ovarian cancer (PROC).
Patients And Methods: NRG-GY005 is an open-label, four-arm, phase II/III superiority trial enrolling patients with high-grade serous/endometrioid PROC and one to three previous therapies. Key exclusion criteria included previous receipt of poly(ADP-ribose) polymerase inhibitor or receipt of antiangiogenic therapy in the recurrent setting.
Medical Students' Experiences of Mistreatment by Clinicians and Academics at a South African University.
Teach Learn Med
January 2024
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Tertiary education in post-apartheid South Africa has faced many challenges regarding class, language, and race. Even though previously white Afrikaans-rooted universities now have a diverse student population, recent student protests have highlighted the ongoing need for decolonization in higher education. In addition, the majority of public hospitals in the country function under significant staffing, infrastructure, and equipment shortages.
View Article and Find Full Text PDF[Return to work in the context of the COVID-19 pandemic in the industrial and construction sectors in Navarre (Spain)].
Arch Prev Riesgos Labor
October 2020
Servicio de Salud Laboral, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain.
Objective: To analyse the compliance of the preventive instructions formulated by the Health Authority against COVID-19 for the de-escalation phase among the industrial and construction sectors in Navarre.
Methods: On the basis of those preventive instructions, questionnaires were drawn up to verify their implementation on site. The occupational risk prevention technicians of the Occupational Health Service (OHS) of the Institute of Public and Work Health of Navarre and those of the External Prevention Services (EPS), under the executive coordination of the OHS, visited the enterprises to advise, verify and require, if necessary, compliance with the instructions dictated.
Real-World Characteristics and Treatment Patterns in Patients with Urticaria Initiating Omalizumab in the United States.
J Manag Care Spec Pharm
July 2018
4 University of Rochester Medical Center, Rochester, New York.
Background: Omalizumab is indicated for the management of chronic idiopathic urticaria (CIU) in patients aged 12 years or older with persistent hives that are not adequately controlled by H1 antihistamines. While its safety and efficacy in CIU patients have been evaluated in multiple clinical trials, real-world use of omalizaumab in CIU has not been well characterized.
Objective: To assess demographics, clinical characteristics, and treatment patterns of CIU patients who initiated omalizumab to better understand the usage of this agent in CIU management in the real world.
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