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A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.
Diabetologia
November 2024
Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Article Synopsis
- Monogenic diabetes results from rare gene mutations affecting beta cell function, and this study examines how common variants may also influence young-onset type 2 diabetes (YOD) and related health issues.
- Researchers created a weighted polygenic risk score (wPRS) using data from individuals with and without YOD to explore the association of 135 common variants across 34 monogenic diabetes genes.
- The findings indicate that higher wPRS correlates with an increased likelihood of YOD and a higher risk for cardiovascular and kidney events in individuals with type 2 diabetes.
Mediterranean Diet Information on TikTok and Implications for Digital Health Promotion Research: Social Media Content Analysis.
JMIR Form Res
June 2024
Baylor College of Medicine, Children's Nutrition Research Center, Houston, TX, United States.
Background: The Mediterranean diet has been linked to reduced risk for several cardiometabolic diseases. The lack of a clear definition of the Mediterranean diet in the scientific literature and the documented proliferation of nutrition misinformation on the internet suggest the potential for confusion among consumers seeking web-based Mediterranean diet information.
Objective: We conducted a social media content analysis of information about the Mediterranean diet on the influential social media platform, TikTok, to examine public discourse about the diet and identify potential areas of misinformation.
Evaluation of a unique and innovative diabetes care model in primary care in Ontario, Canada: protocol for a multiple-methods study with a convergent parallel design.
BMJ Open
June 2024
Department of Family Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Introduction: The growth and complexity of diabetes are exceeding the capacity of family physicians, resulting in the demand for community-based, interprofessional, primary care-led transition clinics. The Primary Care Diabetes Support Programme (PCDSP) in London, Ontario, is an innovative approach to diabetes care for high-risk populations, such as medically or socially complex and unattached patients. In this study, we will employ a quadruple-aim approach to evaluate the health system impacts of the PCDSP.
View Article and Find Full Text PDFIncidence, risk factors, and predictive modeling of stoma site incisional hernia after enterostomy closure: a multicenter retrospective cohort study.
BMC Gastroenterol
June 2023
Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- The study investigates the incidence and risk factors of stoma site incisional hernia (SSIH), which is a common complication after enterostomy closure, to create a predictive model for identifying at-risk patients.
- A retrospective analysis involved 156 patients, with a 24.4% occurrence rate of SSIH, revealing that factors like age, colostomy, BMI, malignant tumors, and emergency surgeries significantly increase the risk.
- The findings led to the development of a predictive model aimed at identifying high-risk patients for SSIH, emphasizing the need for further research on prevention and management strategies for these individuals.
Evaluation of Predictors for Successful Residency Match in General Surgery.
J Surg Educ
May 2022
Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Objective: To determine predictive factors for a successful residency match among general surgery applicants from 2018 to 2021.
Design: A retrospective cross-sectional study of general surgery applicants who matched and went unmatched in match years 2018 to 2021. Applicant characteristics, geographic connections to a program, and away rotations were compared among matched and unmatched applicants.
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