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Background: Although the success rate of novel treatments for CNS diseases is low, this has not limited the enthusiasm of academic and industry neuroscientists to undertake novel drug discovery approaches for the treatment of Alzheimer's Disease-Related Dementias (ADRD) due to the significant unmet need. A first major obstacle in the development of promising treatments for ADRD and other CNS disorders is the need for well-validated targets linked to the disease process. Partial and incomplete knowledge about the biology of the selected molecular target(s) often limit their chance to translate into successful drug discovery projects.
View Article and Find Full Text PDFUse of artificial intelligence for liver diseases: A survey from the EASL congress 2024.
JHEP Rep
December 2024
Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Artificial intelligence (AI) methods enable humans to analyse large amounts of data, which would otherwise not be feasibly quantifiable. This is especially true for unstructured visual and textual data, which can contain invaluable insights into disease. The hepatology research landscape is complex and has generated large amounts of data to be mined.
View Article and Find Full Text PDFPI-RADS v2.1 evaluation of prostate "nodule in nodule" variants: clinical, imaging, and pathological features.
Insights Imaging
March 2024
Department of Urology, the Fuyang Hospital of Anhui Medical University, Yingzhou District, No. 99, Mount Huangshan Road, Fuhe Modern Industrial Park, Fuyang, Anhui Province, 236000, People's Republic of China.
Objectives: To analyze the correlation among the imaging features of prostate "nodule in nodule," clinical prostate indices, and pathology results.
Methods: We retrospectively analyzed the prostate images from 47 male patients who underwent MRI scans and pathological biopsy from January 2022 to July 2023. Two radiologists (R1/R2) evaluated the morphology and signal intensity of the "nodule in nodule" in a double-blind manner and calculated the PI-RADS v2.
Sugar labeling information and online marketing strategies for hand-shaken tea drinks in northern Taiwan.
Front Nutr
November 2023
School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.
Background: Sugar-sweetened beverages (SSBs) are the main cause of excessive sugar intake and increased health risks. Food companies usually use social media to market SSBs in order to increase consumers' purchase intentions. To reduce excessive added sugar consumption from hand-shaken tea drinks, Taiwan has implemented a mandatory policy requiring clear sugar content labeling.
View Article and Find Full Text PDFHidden risk of gadolinium-based contrast agents during interventional pain medicine procedures: a retrospective chart review.
Reg Anesth Pain Med
October 2024
Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA
Introduction: Epidural steroid injections and epidural blood patches commonly involve the injection of a small amount of radiocontrast media under fluoroscopy to properly identify the target tissue or anatomic space and prevent off-target or intravascular delivery of therapeutic or diagnostic drugs. Iodinated low osmolar non-ionic contrast media is the standard preparation used as it is considered safe and cost-effective, but gadolinium-based preparations have been used as an alternative for patients with an 'iodine'-related or radiocontrast media allergy label to prevent hypersensitivity reactions. The risk of neurotoxic events when gadolinium is inadvertently injected into the intrathecal space has been reported in recent years, raising concerns when gadolinium-based contrast media is used in lieu of iodinated low osmolar non-ionic contrast media.
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