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Background: People living with dementia (PWD) have upregulated inflammatory pathways, exaggerated metabolic aging, and cellular aging. They also have declines in physical function and heightened fall-risk. Understanding the physiologic factors that influence physical decline and fall-risk in PWD is vital to assess and prevent adverse health outcomes, such as future falls.
View Article and Find Full Text PDFCritical review of aging clocks and factors that may influence the pace of aging.
Front Aging
December 2024
Integrative Research Institute, Sacramento, CA, United States.
Background And Objectives: Aging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently available aging clocks, ranging from epigenetic aging clocks to visual skin aging clocks.
Methods: We performed a literature search on PubMed/MEDLINE databases with keywords including: "aging clock," "aging," "biological age," "chronological age," "epigenetic," "proteomic," "microbiome," "telomere," "metabolic," "inflammation," "glycomic," "lifestyle," "nutrition," "diet," "exercise," "psychosocial," and "technology.
Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLD.
J Gastroenterol
November 2024
Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
Background: The biological process of aging plays an important role in the progress of liver fibrosis. However, epidemiological evidence about the associations between advanced fibrosis and epigenetic age acceleration (EAA) among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is limited.
Methods: We utilized publicly available DNA methylation data (GSE180474) for our analysis.
Telomere length and cognitive changes in 7,877 older UK adults of European ancestry.
Front Aging
November 2024
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Background: Telomere length (TL) has been linked to cognitive function, decline and dementia. This study aimed to explore whether both measured TL and genetic disposition for TL predict dimensions of cognitive performance in a longitudinal sample of older UK adults.
Methods: We analysed data from PROTECT study participants aged ≥50 years without a dementia diagnosis, who had completed longitudinal cognitive testing.
Evaluating the connection between diet quality, EpiNutrient intake and epigenetic age: an observational study.
Am J Clin Nutr
November 2024
Laboratory of Nutrition and Metabolic Epigenetics, Department of Health Sciences and Technology, ETH Zurich, Switzerland. Electronic address:
Background: DNA methylation (DNAm) has unique properties which makes it a potential biomarker for lifestyle-related exposures. Epigenetic clocks, particularly DNAm-based biological age predictors [epigenetic age (EA)], represent an exciting new area of clinical research and deviations of EA from chronological age [epigenetic age acceleration (EAA)] have been linked to overall health, age-related diseases, and environmental exposures.
Objectives: This observational study investigates the relationships between biological aging and various dietary factors within the LifeLines-DEEP Cohort.
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