Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A Violation of Occam's Razor: Acute Appendicitis after Motor Vehicle Collision.
Am Surg
September 2016
Division of Acute Care Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA.
Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions.
J Biol Chem
December 2011
Molecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
RtcB enzymes are a newly discovered family of RNA ligases, implicated in tRNA splicing and other RNA repair reactions, that seal broken RNAs with 2',3'-cyclic phosphate and 5'-OH ends. Parsimony and energetics would suggest a one-step mechanism for RtcB sealing via attack by the O5' nucleophile on the cyclic phosphate, with expulsion of the ribose O2' and generation of a 3',5'-phosphodiester at the splice junction. Yet we find that RtcB violates Occam's razor, insofar as (i) it is adept at ligating 3'-monophosphate and 5'-OH ends; (ii) it has an intrinsic 2',3'-cyclic phosphodiesterase activity.
View Article and Find Full Text PDFOn violating Occam's razor.
South Med J
June 1991
VA Medical Center, Department of Medicine, St. Louis, MO 63104.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!