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Distinctive neuronal firing patterns in subterritories of the subthalamic nucleus. | LitMetric

AI Article Synopsis

  • Deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective for treating Parkinson's disease and is based on targeting specific functional areas within the STN: sensorimotor, limbic, and associative.
  • This study involved analyzing microelectrode recordings from 30 Parkinson's patients to differentiate electrical activity in the dorsal (dSTN) and ventral (vSTN) regions of the STN.
  • Results indicated distinct burst firing patterns between dSTN and vSTN, suggesting that these areas may have different roles in regulating motor function.

Article Abstract

Objective: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for Parkinson's disease (PD). Anatomical connectivity analyses and task-related physiological studies have divided the STN into different functional domains: sensorimotor, limbic, and associative - located in its dorsolateral (dSTN), anteroventral (vSTN) and medial territories, respectively. Targeting sensorimotor STN is essential for stimulation efficacy and is supported by intraoperative micro-electrode recordings. A different neuronal signature in microelectrode recordings across STN subterritories was explored in this study.

Methods: Stable recordings from 30 PD patients were assigned to dSTN or vSTN by means of an anatomical method (based on fused computed tomography/magnetic resonance images) and through a priori tri-segmented partition of the recording itself. We computed the inter-spike interval (ISI) and ISI-characteristics, mean firing rate (MFR), discharge patterns and mean burst rate (MBR) of each detected single unit activity.

Results: We showed a different MBR between dSTN and vSTN (1.51±0.18 vs. 1.76±0.22events/minute, Wilcoxon rank sum test, p<0.05) and a trend in the difference between their MFR (12.78 vs. 15.05Hz, Wilcoxon rank sum test, p=0.053) only with the anatomically based method.

Conclusion: Burst firing differs across STN subterritories.

Significance: Different functions of subthalamic domains might be reflected by distinctive burst signalling of its subterritories.

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Source
http://dx.doi.org/10.1016/j.clinph.2016.09.004DOI Listing

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