Some alpha-methylene-gamma-lactone derivatives of substituted nucleic acid bases, which showed significant antitumour activity against experimental tumours, were tested for their possible mechanism of action. Derivatives 1, 4 and 7 strongly inhibit active transport of uridine through sarcoma-180 ascites tumour cells. Derivatives 1, 7 and 10 strongly inhibit a translation process in these cells, besides apparent inhibition in transcription. It appears that active transport and translation might be the primary steps inhibited by these drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000238667 | DOI Listing |
Publication Analysis
Top Keywords
mechanism action
8
alpha-methylene-gamma-lactone derivatives
8
derivatives substituted
8
substituted nucleic
8
nucleic acid
8
acid bases
8
tumour cells
8
derivatives inhibit
8
active transport
8
action alpha-methylene-gamma-lactone
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!