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| http://dx.doi.org/10.21037/sci.2016.08.03 | DOI Listing |
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Regulatory network analysis of gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression.
bioRxiv
October 2024
Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.
expression defines a rare population of cells in the normal pancreas whose frequency is increased at early stages of pancreatic tumorigenesis. The identity and the precise roles of expressing cells in pancreas have been matter of debate, although evidence suggests their involvement in a number of key functions, including regeneration and neoplasia. We employed a recently developed Dclk1 reporter mouse model and single cell RNAseq analysis to define expressing cells in normal pancreas and pancreatic neoplasia.
View Article and Find Full Text PDFE74-like ETS transcription factor 1 promotes the progression of pancreatic cancer by regulating doublecortin-like kinase 1/Janus kinase/signal transducer and activator of transcription pathway.
Am J Cancer Res
February 2024
Department of Hepato-Pancreato-Biliary Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310009, Zhejiang, China.
This study was targeted at investigating the biological functions of E74-like ETS transcription factor 1 (ELF1) in pancreatic cancer (PC) and its underlying mechanism. ELF1 expression in PC tissues was detected by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemistry. Cell counting kit-8 (CCK-8) method, EdU method and flow cytometry were used to detect the cell proliferation and apoptosis of PC cell lines after transfection.
View Article and Find Full Text PDFProtein kinase D1 - A targetable mediator of pancreatic cancer development.
Biochim Biophys Acta Mol Cell Res
February 2024
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA. Electronic address:
Members of the Protein kinase D (PKD) kinase family each play important cell-specific roles in the regulation of normal pancreas functions. In pancreatic diseases PKD1 is the most widely characterized isoform with roles in pancreatitis and in induction of pancreatic cancer and its progression. PKD1 expression and activation increases in pancreatic acinar cells through macrophage secreted factors, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling, and reactive oxygen species (ROS), driving the formation of precancerous lesions.
View Article and Find Full Text PDFDesign, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer.
Eur J Med Chem
December 2023
Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China; Department of Pharmacology, China Pharmaceutical University, Nanjing 211198, China. Electronic address:
Pancreatic cancer is a highly lethal form of malignancy that continues to pose a significant and unresolved health challenge. Doublecortin-like kinase 1 (DCLK1), a serine/threonine kinase, is found to be overexpressed in pancreatic cancer and holds promise as a potential therapeutic target for this disease. However, few potent inhibitors have been reported currently.
View Article and Find Full Text PDFTff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.
Cell Stem Cell
August 2023
Division of Digestive and Liver Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:
Article Synopsis
- Scientists found that special cells in the pancreas, called Tff2 cells, can help repair damage and keep the pancreas healthy.
- When the pancreas gets hurt, these Tff2 cells can reduce in number but can grow back later.
- If Tff2 cells are removed before cancer starts, it makes it easier for tumors to form, but adding Tff2 back can help protect against this cancer.
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