AI Article Synopsis
- Autoimmune reactions in periodontal diseases arise from an imbalance between immune responses, involving stages of initiation, propagation, and phases of remission and exacerbation.
- Periodontal diseases lead to inflammation in tooth-supporting structures, significantly contributing to tooth loss, with autoimmune responses shown to be involved in their development.
- Key components such as autoreactive T-cells, natural killer cells, autoantibodies, and various genetic factors contribute to the autoimmune aspect of periodontal disease, emphasizing the need for understanding these mechanisms.
Article Abstract
Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and often show phases of resolution (indicated by clinical remissions) and exacerbations (indicated by symptomatic flares). The fundamental underlying mechanism of autoimmunity is defective elimination and/or control of self-reactive lymphocytes. Periodontal diseases are characterized by inflammatory conditions that directly affect teeth-supporting structures, which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidence of involvement of immunopathology has been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T-cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses.
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| http://dx.doi.org/10.1016/j.autrev.2016.09.013 | DOI Listing |
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