Mode division multiplexing (MDM) has been widely investigated in optical transmission systems and networks to improve network capacity. However, the MDM receiver is always expensive and complex because coherent detection and multiplex-input-and-multiplex-output (MIMO) digital signal processing (DSP) are required to demultiplex each spatial mode. In this paper, we investigate the application of MDM in short-reach scenarios such as datacenter networking. Two-dimensional MDM and wavelength division multiplexing node structure based on low modal-crosstalk few-mode fiber (FMF) and components is proposed, in which signal in each mode or wavelength can be independently switched. We experimentally demonstrate independent adding, dropping and switching functionalities with two linearly polarized modes and four wavelength channels over a total 11.8-km 2-mode low modal-crosstalk FMFs. The structure is simple without coherent detection or MIMO DSP. Only slight penalties of receiver sensitivity are observed for all switching operations. The influence of modal-crosstalk accumulation for cascaded switching nodes is also investigated.
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http://dx.doi.org/10.1364/OE.24.021609 | DOI Listing |
ACS Infect Dis
January 2025
Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan 48824, United States.
Group B (GBS) is a major cause of fetal and neonatal mortality worldwide. Many of the adverse effects of invasive GBS are associated with inflammation; therefore, understanding bacterial factors that promote inflammation is of critical importance. Membrane vesicles (MVs), which are produced by many bacteria, may modulate host inflammatory responses.
View Article and Find Full Text PDFFASEB J
January 2025
HSS Research Institute, Hospital for Special Surgery, New York, New York, USA.
Aging is a risk factor for several chronic conditions, including intervertebral disc degeneration and associated back pain. Disc pathologies include loss of reticular-shaped nucleus pulposus cells, disorganization of annulus fibrosus lamellae, reduced disc height, and increased disc bulging. Sonic hedgehog, cytokeratin 19, and extracellular matrix proteins are markers of healthy disc.
View Article and Find Full Text PDFInt Endod J
January 2025
Department of Endodontics, Centre of Oral Clinical and Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, Guy's Dental Hospital, King's College London, London, UK.
Aims: Apical Periodontitis (AP) involves complex interactions between the root canal microbiome and the host immune response, with potential risk of local and systemic inflammatory burden, however there is no evidence available regarding correlation between microbiome and inflammatory marker levels. This study aims to identify the microbiome of saliva, intracanal and blood samples in AP subjects and investigate the correlation between intracanal and blood microbiomes with serum inflammatory biomarker levels, and salivary microbiomes with salivary inflammatory biomarker levels.
Methodology: Saliva, Intracanal and blood samples were collected from AP patients undergoing root canal retreatment.
Clin Genet
January 2025
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Arthrogryposis multiplex congenita (AMC) is a heterogeneous disorder associated with 1/3000 to 1/5000 live births. We report a consanguineous family with multiple affected members with AMC and identified a recessive mutation in the highly conserved splice donor site, resulting in the mis-splicing of the affected exons. SENP7 is a deSUMOylase that is critical for sarcomere assembly and skeletal muscle contraction by regulating the transcriptional program in the skeletal muscle.
View Article and Find Full Text PDFBreast Cancer Res
January 2025
Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Background: Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), with lack of breastfeeding. This is more prevalent in African American women, with significantly lower rate of breastfeeding compared to Caucasian women. Prolonged breastfeeding leads to gradual involution (GI), whereas short-term or lack of breastfeeding leads to abrupt involution (AI) of the breast.
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