THE ROLE OF POLYMORPHISM - 634 G/C (RS 2010963) OF VEGF-A GENE IN THE DEVELOPMENT OF HYPERTENSION AND OBESITY IN PREMENOPAUSAL WOMEN.

The study of genetic dependency of developing cardiovascular diseases and factors of endothelial dysfunction in menopausal women is extremely important in today's world. The aim of the study was to assess the correlation of polymorphic marker -634G/С (rs2010963) of the VEGF-А gene and formation of AH combined with obesity in premenopausal women. The data of 115 women with stage II of AH, grade 1-2 and obesity I-II gr., aged 45 to 60 years. All patients were divided into groups according to menopausal status: 45 women without menopause (premenopausal), and who were registered with irregular menstrual cycle for 3-11 months, and 50 menopausal women whose period is less than 3 years. The control group was consisted of 20 healthy perimenopausal women matched by age. The VEGF concentration was determined by ELISA. The study of the allelic polymorphism -634 G/C (rs 2010963) VEGF-А gene was performed by polymerase chain reaction. It was found that the GG genotype polymorphism -634 G/C (rs 2010963) of the VEGF-А gene is more common among women with hypertension and obesity in premenopause, than in the menopause group. It was shown that the level of VEGF was significantly higher among premenopausal and menopausal women with the GG genotype polymorphism -634 G/C (rs 2010963) of the VEGF-А gene compared with genotypes GC and CC patients (p<0.05). The carriage of the GG genotype polymorphism -634 G/C (rs 2010963) of the VEGF-А gene can be considered as an early marker of the cardiovascular risk development of hypertensive disease combined with an obesity among perimenopausal patients.