AI Article Synopsis
- Hypertension is linked to serious health issues, with serum gamma-glutamyl transpeptidase (GGT) serving as a biomarker that indicates higher risks of hypertension and diabetes.
- The study involved 171 hypertensive patients, categorizing them into "dippers" (normal nighttime blood pressure drop) and "non-dippers" (minimal drop), finding that non-dippers were generally older and had elevated levels of GGT, C-reactive protein, and uric acid.
- Higher GGT levels in the non-dipper group were associated with less nighttime blood pressure decrease, suggesting a potential link between GGT levels and blood pressure regulation, but more extensive studies are needed for confirmation.
Article Abstract
Background: Hypertension is a very important cause of morbidity and mortality. Serum gamma-glutamyl transpeptidase (GGT) is a biomarker of oxidative stress and associated with increased risk of hypertension and diabetes. The aim of this study was to evaluate the association of serum GGT level, which is an early marker of inflammation and endothelial dysfunction, with the deterioration of the diurnal rhythm of the blood pressure.
Methods: A total of 171 patients with hypertension were included in this study. Patients whose nighttime mean blood pressure, measured via ambulatory blood pressure monitoring, decreased between 10% and 20% compared with the daytime mean blood pressure were defined as "dippers", whereas patients with a nighttime blood pressure decrease lower than 10% were defined as "non-dippers".
Results: A total of 99 hypertensive patients (65 females/34 males) were classified as dippers and 72 patients (48 females/24 males) as non-dippers. The mean age of the non-dipper group was significantly greater than the dipper group. Serum GGT, C-reactive protein and uric acid levels were significantly higher among patients in the non-dipper group. Negative correlations were detected between GGT levels and diurnal systolic and diastolic blood pressure decreases.
Conclusion: Our findings revealed that GGT level was higher in the non-dipper group, and was negatively correlated with the nighttime decrease of diurnal blood pressure. C-reactive protein and uric acid levels were also higher in the non-dipper group. However, future randomized controlled prospective studies with larger patient populations are necessary to confirm our findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019468 | PMC |
| http://dx.doi.org/10.2147/TCRM.S116603 | DOI Listing |
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