AI Article Synopsis
- - The study aimed to investigate whether T1-weighted MR signals from the pancreas can effectively identify early chronic pancreatitis (CP) in patients.
- - A total of 51 patients were analyzed, comparing those with normal and low bicarbonate levels using secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST).
- - Results showed a significant difference in the pancreas-to-spleen signal intensity ratio (SIR) between the two groups, with SIR values indicating a high sensitivity (77%) and specificity (83%) for detecting pancreatic exocrine dysfunction, making T1-weighted MR signals valuable in evaluating early CP. *
Article Abstract
Purpose: To determine if T1-weighted MR signal of the pancreas can be used to detect early CP.
Methods: A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST. Signal intensity ratio of pancreas (SIR), fat signal fraction, pancreatograms findings, and grade of duodenal filling were recorded on S-MRCP by two blinded radiologists.
Results: There was a significant difference in the signal intensity ratio of the pancreas to spleen (SIR) between the normal and low bicarbonate groups (p < 0.0001). A significant positive correlation was found between pancreatic fluid bicarbonate level and SIR (p < 0.0001). SIR of 1.2 yielded sensitivity of 77% and specificity of 83% for detection of pancreatic exocrine dysfunction (AUC: 0.89).
Conclusion: T1-weighted MR signal of the pancreas has a high sensitivity and specificity for the detection of parenchymal abnormalities related to exocrine dysfunction and can therefore be helpful in evaluation of suspected early CP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542580 | PMC |
| http://dx.doi.org/10.1007/s00261-016-0917-2 | DOI Listing |
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