Significance of Echocardiographically Detected Central Venous Catheter Tip-Associated Thrombi.

J Vasc Interv Radiol

From the Department of Radiology, Division of Interventional Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address:

Published: December 2016

AI Article Synopsis

  • The study examined the occurrence and management of thrombi (blood clots) associated with central venous catheters (CVCs) found through echocardiography, involving data from 170 patients.
  • Among the 49 patients with CVC tip-associated thrombi, most showed no complications after management decisions were made, even though some were on anticoagulation therapy.
  • The findings suggest that these thrombi may pose little risk, indicating that aggressive treatments like anticoagulation or catheter removal might not be necessary for patients without other complicating factors like patent foramen ovale (PFO).

Article Abstract

Purpose: To explore significance, management, and outcomes of central venous catheter (CVC) tip-associated thrombi incidentally detected on echocardiography.

Materials And Methods: Echocardiogram data from all patients with CVCs from October 2009 to June 2011 were reviewed (N = 170). Patients with CVC tip-associated thrombi were selected (n = 49). Echocardiograms were reviewed for ejection fraction, presence of patent foramen ovale (PFO), presence of other intracardiac shunts, and mean thrombus size. Management decisions, thrombus extension, pulmonary embolism, paradoxical emboli, and stroke within 3 months were recorded.

Results: Mean thrombus size was 2.1 cm (range, 0.5-5.7 cm). Of patients with thrombi, 11 (22%) were already on anticoagulation, and there was no change in management. Anticoagulation was started without complications in 17 (35%) patients, the catheter was removed in 4 (8%) patients, and no new treatment was initiated in 17 (35%) patients. Of these 17 patients, 16 (94%) developed no complications. One (6%) patient with a PFO and right-to-left shunt experienced a stroke before PFO closure. After surgical closure of the PFO, the same patient developed catheter tip-associated thrombus without complication. There were no pulmonary emboli, strokes, or other detected embolic phenomena.

Conclusions: In this sample with CVC tip-associated thrombi but without PFO or other intracardiac shunts, no embolic or other complications were detected, regardless of anticoagulation status. These data suggest a benign course for such thrombi and that anticoagulation, catheter removal, thrombectomy, and thrombolysis may be unnecessary when catheter tip-associated thrombi are incidentally detected on echocardiography.

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http://dx.doi.org/10.1016/j.jvir.2016.07.013DOI Listing

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Significance of Echocardiographically Detected Central Venous Catheter Tip-Associated Thrombi.

J Vasc Interv Radiol

December 2016

From the Department of Radiology, Division of Interventional Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address:

Article Synopsis
  • The study examined the occurrence and management of thrombi (blood clots) associated with central venous catheters (CVCs) found through echocardiography, involving data from 170 patients.
  • Among the 49 patients with CVC tip-associated thrombi, most showed no complications after management decisions were made, even though some were on anticoagulation therapy.
  • The findings suggest that these thrombi may pose little risk, indicating that aggressive treatments like anticoagulation or catheter removal might not be necessary for patients without other complicating factors like patent foramen ovale (PFO).
View Article and Find Full Text PDF

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