Re-engineering the Hippocampus.

Neuron

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

Published: September 2016

New neurons created in adults compete with older neurons for connections in the hippocampus.
Research by McAvoy et al. (2016) shows that reducing the spines on mature neurons helps new neurons to establish connections more effectively.
This integration of new neurons enhances the brain's ability to learn.

As adult-generated neurons integrate into hippocampal circuits, they compete with mature neurons for inputs from the entorhinal cortex. By reducing spines on mature granule cells, McAvoy et al. (2016) find that new neurons integrate more efficiently, and this facilitates learning.

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http://dx.doi.org/10.1016/j.neuron.2016.09.008	DOI Listing

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