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Primary ciliary dyskinesia as a rare cause of male infertility: case report and literature overview.
Basic Clin Androl
December 2024
RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
Background: Primary ciliary dyskinesia (PCD) is a heterogenous disease caused by mutations of miscellaneous genes which physiologically play an important role in proper structure and/or function of various cellular cilia including sperm flagella. Besides male infertility, the typical phenotypes, based on decreased mucociliary clearance, are lifelong respiratory issues, i.e.
View Article and Find Full Text PDFEffect of graded exercise rehabilitation based on pulmonary function classification on dyspnea, pulmonary function, and exercise capacity in elderly lung cancer patients.
Am J Transl Res
November 2024
Department of Rehabilitation, Panjin Liao He Oil Field Gem Flower Hospital Panjin 124010, Liaoning, China.
Objective: To investigate the effects of graded exercise rehabilitation training tailored to pulmonary function classification on dyspnea, pulmonary function, and exercise capacity during postoperative rehabilitation in elderly patients following lung cancer surgery.
Methods: A retrospective analysis was conducted on clinical data from 168 elderly patients undergoing postoperative rehabilitation after lung cancer surgery at Panjin Liaohe Oilfield Gem Flower Hospital from January 2021 to December 2022. Patients were divided into two groups based on the rehabilitation received: the control group (n=71), receiving standard rehabilitation, and the study group (n=97), receiving additional graded exercise rehabilitation based on pulmonary function classification.
Clinical, biochemical, and genetic study of TACE/TNF-α/ACE signaling pathway in pediatric COVID-19 infection.
Clin Exp Pediatr
December 2024
Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
Background: Pediatric patients infected with coronavirus disease 2019 (COVID-19) have unique clinical characteristics. Tumor necrosis factor (TNF) is a proinflammatory cytokine that greatly contributes to tumor pathogenesis.
Purpose: To describe the presenting characteristics of COVID-19 infection among pediatric patients, and investigate the possible role of the TNF-α signaling pathway.
The effector protein BteA induces host cell death by disruption of calcium homeostasis.
mBio
December 2024
Laboratory of Infection Biology, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
is the causative agent of whooping cough in humans, a disease that has recently experienced a resurgence. In contrast, infects the respiratory tract of various mammalian species, causing a range of symptoms from asymptomatic chronic carriage to acute illness. Both pathogens utilize type III secretion system (T3SS) to deliver the effector protein BteA into host cells.
View Article and Find Full Text PDFIntranasal sensitization model of alopecia areata using pertussis toxin as adjuvant.
Front Immunol
October 2024
Division of Pediatric Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Article Synopsis
- The study focuses on the effects of pertussis toxin (PTx) from Bordetella pertussis and its potential to induce autoimmune responses in mice, specifically examining its interaction with myelin oligodendrocyte peptide (MOG).
- Mice administered PTx and MOG didn't develop experimental autoimmune encephalomyelitis (EAE) but exhibited patchy alopecia in 36.4% of cases, linked to immune system changes around hair follicles.
- Histological analysis confirmed alopecia areata characteristics, showing a disruption of hair follicle immune privilege and increased immune cell activity, highlighting a potential connection between PTx exposure and immune system disorders.
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