AI Article Synopsis
- Lymph node metastases in prostate cancer show a better prognosis than distant metastatic spread, indicating different underlying causes.
- Researchers studied cancer spread by analyzing genetic profiles of samples from patients with lymph node and bone metastases.
- Findings suggest that lymph node metastases originate from more evolved tumor cells, while bone metastases come from a wider variety of tumor cell origins, indicating that lymph node and bone metastases are distinct in their development.
Article Abstract
The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metastatic spread, suggesting the possibility of distinct aetiologies. To explore this, we traced patterns of cancer dissemination using tumour phylogenies inferred from genome-wide copy-number profiling of 48 samples across 3 patients with lymph node metastatic disease and 3 patients with osseous metastatic disease. Our results show that metastatic cells in regional lymph nodes originate from evolutionary advanced extraprostatic tumour cells rather than less advanced central tumour cell populations. In contrast, osseous metastases do not exhibit such a constrained developmental lineage, arising from either intra or extraprostatic tumour cell populations, at early and late stages in the evolution of the primary. Collectively, this comparison suggests that lymph node metastases may not be an intermediate developmental step for distant osseous metastases, but rather represent a distinct metastatic lineage.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031992 | PMC |
| http://dx.doi.org/10.1038/srep33918 | DOI Listing |
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