AI Article Synopsis
- Equine herpesvirus myeloencephalopathy (EHM) is a serious condition resulting from equine herpesvirus 1 (EHV-1), and effective prevention and treatment options are currently lacking.
- A study was conducted during an EHV-1 outbreak where 31 febrile horses received heparin treatment, while 30 febrile horses did not.
- Results showed that heparin-treated horses had a significantly lower incidence of EHM (3.2%) compared to untreated horses (23.3%), suggesting heparin could be beneficial, but further randomized studies are needed.
Article Abstract
Equine herpesvirus myeloencephalopathy (EHM) is a severe manifestation of equine herpesvirus 1 (EHV-1) infection. Prevention and treatment of EHM during EHV-1 outbreaks is critical, but no reliable and tested specific medication is available. Due to the thromboischemic nature of EHM and due to the fact that EHV-1 entry in cells is blocked by heparin, it was hypothesized that this compound may be useful in reduction of EHM incidence and severity. Therefore, during an acute EHV-1 outbreak with the neuropathogenic G/D Pol variant, metaphylactic treatment with heparin to prevent EHM was initiated. Clinical signs were present in 61 horses (fever n = 55; EHM n = 8; abortion n = 6). Heparin (25000 IU subcutaneously twice daily for 3 days) was given to 31 febrile horses from day 10 of the outbreak, while the first 30 horses exhibiting fever remained untreated. Treatment outcome was analyzed retrospectively. Heparin-treated horses showed a lower EHM incidence (1/31; 3.2%) than untreated horses (7/30; 23.3%; p = 0.03). Results indicate that heparin may be useful for prevention of EHM during an EHV-1 outbreak. These promising data highlight the need for randomized and possibly blinded studies for the use of heparin in EHV-1 outbreaks.
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| http://dx.doi.org/10.15653/TPG-150451 | DOI Listing |
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Article Synopsis
- Equine herpesvirus type 1 (EHV-1) enters horses through the upper respiratory tract, where mucosal immunity plays a key role in fighting the virus.
- A study collected intranasal immune cells from horses during EHV-1 infection, finding that CD4 and CD8 T cells increased significantly after the infection.
- Researchers identified distinct roles for these T cells in healthy horses and during infection, revealing specific patterns of accumulation in nasal tissue and a lack of response from mucosal T cells to EHV-1 upon re-stimulation.
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