NBR2: A former junk gene emerges as a key player in tumor suppression.

Mol Cell Oncol

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Published: July 2016

NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972102PMC
http://dx.doi.org/10.1080/23723556.2016.1187322DOI Listing

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