Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972117 | PMC |
| http://dx.doi.org/10.1080/23723556.2016.1183743 | DOI Listing |
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