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Human internal and external exposure to synthetic musks in China.
Ecotoxicol Environ Saf
December 2024
Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao, Shandong 266237, China; Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao, Shandong 266237, China.
The widespread utilization of synthetic musks (SMs) in various consumer and personal care products (PCPs) has led to human external exposure through dermal absorption, inhalation of volatile fragrances, and ingestion of contaminated foods, dust, and liquids. Nonetheless, investigations comparing external and internal exposures in humans remain limited in China, particularly regarding internal exposure assessments in blood, which have lacked follow-up over the past decade. In this study, data concerning the concentrations of SMs in 135 blood samples (68 females and 67 males) obtained from residents of Shanghai are provided, representing the sole publication within the last decade on this topic.
View Article and Find Full Text PDFDermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis.
FASEB J
September 2024
Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China.
Dermal white adipose tissue (DWAT) is a distinctive adipose depot located within the lower dermis of the skin. Its significance as an ancillary fat in skin homoeostasis has recently received increased attention. New research has revealed that DWAT responses to skin pathology and physiology changes, impacting skin development, hair cycling, defense mechanisms, and fibrotic conditions.
View Article and Find Full Text PDFMechanistic insights into cadmium exacerbating 2-Ethylhexyl diphenyl phosphate-induced human keratinocyte toxicity: Oxidative damage, cell apoptosis, and tight junction disruption.
Ecotoxicol Environ Saf
September 2024
Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China. Electronic address:
Organophosphate flame retardants 2-ethylhexyldiphenyl phosphate (EHDPP) and cadmium (Cd) are ubiquitous in environmental matrices, and dermal absorption is a major human exposure pathway. However, their detrimental effects on the human epidermis remain largely unknown. In this study, human keratinocytes (HaCaT cells) were employed to examine the toxicity and underlying mechanisms of co-exposure to EHDPP and Cd.
View Article and Find Full Text PDFGene therapy based on the CRISPR/Cas9 system has emerged as a promising strategy for treating the monogenic fragile skin disorder recessive dystrophic epidermolysis bullosa (RDEB). With this approach problematic wounds could be grafted with gene edited, patient-specific skin equivalents. Precise gene editing using homology-directed repair (HDR) is the ultimate goal, however low efficiencies have hindered progress.
View Article and Find Full Text PDFMicroblading reaction as a manifestation of systemic sarcoidosis: two case reports and a review of the literature.
J Med Case Rep
April 2024
Dermatology and Venereology Clinic, University Medical Centre Ljubljana, Gradiskova 10, 1000, Ljubljana, Slovenia.
Background: Sarcoidosis is a multisystemic disease characterized by granulomatous inflammation. Sarcoidosis often poses a diagnostic challenge owing to its nonspecific or mild clinical features. In 20-35% of cases, sarcoidosis initially presents on skin.
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