AI Article Synopsis
- Phosphatidylethanolamine, a vital phospholipid, is mainly produced by phosphatidylserine decarboxylases (PSD), with a focus on the different PSD types across various life kingdoms.
- In eukaryotes, type I PSDs function as mitochondrial enzymes, while other types are found in different cellular areas, emphasizing their diverse roles.
- The article delves into the specifics of mitochondrial Psd1 proteins, covering their function, assembly, and importance in maintaining phospholipid balance, alongside a brief discussion on the enzymology of Psd2.
Article Abstract
Phosphatidylethanolamine is one of the most abundant phospholipids whose major amounts are formed by phosphatidylserine decarboxylases (PSD). Here we provide a comprehensive description of different types of PSDs in the different kingdoms of life. In eukaryotes, type I PSDs are mitochondrial enzymes, whereas other PSDs are localized to other cellular compartments. We describe the role of mitochondrial Psd1 proteins, their function, enzymology, biogenesis, assembly into mitochondria and their contribution to phospholipid homeostasis in much detail. We also discuss briefly the cellular physiology and the enzymology of Psd2. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
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| http://dx.doi.org/10.1016/j.bbalip.2016.09.007 | DOI Listing |
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