Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering.

J Funct Biomater

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.

Published: September 2016

Multifunctional tissue scaffold material nanodiamond (ND)/chitosan (CS) composites with different diamond concentrations from 1 wt % to 5 wt % were synthesized through a solution casting method. The microstructure and mechanical properties of the composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and nanoindentation. Compared with pristine CS, the addition of ND resulted in a significant improvement of mechanical properties, including a 239%, 276%, 321%, 333%, and 343% increase in Young's modulus and a 68%, 96%, 114%, 118%, and 127% increase in hardness when the ND amount was 1 wt %, 2 wt %, 3 wt %, 4 wt %, and 5 wt %, respectively. The strong interaction between ND surface groups and the chitosan matrix plays an important role in improving mechanical properties.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041000PMC
http://dx.doi.org/10.3390/jfb7030027DOI Listing

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