Differentiated embryonic chondrocyte expressed gene 2 (DEC2; BHLHE41/Sharp1) is a helix-loop-helix (bHLH) transcription factor, and its deregulation has been observed in several tumors. However, this gene's effects on tumor progression are controversial, and its roles in gastric cancer (GC) remain unclear. In the present study, we found that DEC2 expression level is lower in GC tissues compared with adjacent non-tumor tissues, and negatively correlated with tumor invasion, lymph node metastasis, TNM stage, and poor survival of GC patients. Positive clinical correlations of DEC2 with EMT regulator, E-cadherin, were also observed in the tissue sections. Overexpression of DEC2 inhibits cell proliferation and EMT in vitro, as well as tumor growth and metastasis in vivo. DEC2 expression also induces cell apoptosis. Furthermore, the anti-metastatic effect of DEC2 was mediated by inhibiting ERK/NF-κB/EMT axis. After treatment with ERK1/2 chemical inhibitor (U0126), DEC2's inhibitory effect on ERK/NF-κB/EMT was further decreased. Collectively, these data helped to characterize DEC2, which might be a potential molecular target for diagnostic and therapeutic approaches for GC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004076 | PMC |
Publication Analysis
Top Keywords
Similar Publications
External load transition practices from pre-season to in-season. A case study in elite female professional soccer players.
PLoS One
December 2024
Life Quality Research Centre (CIEQV-IP Setúbal), Campus do IPS-Estefanilha, Setúbal, Portugal.
The study aim was to compare the external load during varying microcycles (M1-M4 during pre-season and M5 during the in-season) in elite female Portuguese soccer players and to describe external load variations between differing Ms. Fourteen first-team players participated in the study (age 23.29 ± 3.
View Article and Find Full Text PDFSleep deprivation alters hepatic UGT1A9 and propofol metabolism in mice.
Biochem Pharmacol
December 2024
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR China. Electronic address:
Sleep deprivation (SD) causes circadian misalignment, and circadian clock disruption is associated with metabolic diseases such as obesity, insulin resistance, and diabetes. However, the underlying mechanism for SD-induced circadian clock disruption as well as metabolic enzyme changes is still lacking. Here, we developed SD sensitizes mice with disrupted circadian rhythms to demonstrate the regulation role and mechanism of SD in UDP-glucuronosyltransferases (UGTs) expression and the metabolism of corresponding substrates.
View Article and Find Full Text PDFCancer-associated fibroblasts-derived CXCL1 activates DEC2-mediated dormancy in oral squamous cell carcinoma.
Heliyon
October 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) influence cancer progression and the dormant state of oral squamous cell carcinoma (OSCC) cells, which is not well-understood.
- A study of 61 OSCC patients revealed that lower levels of the DEC2 gene linked to tumor recurrence and the presence of CAFs, suggesting a key role of DEC2 in cellular dormancy.
- CAFs secrete C-X-C motif ligand 1 (CXCL1) which reduces DEC2 expression in OSCC cells, "awakening" dormant cells and potentially leading to cancer recurrence, highlighting a possible target for new therapies.
A comparative analysis of weekly internal and external workloads between starting and non-starting professional soccer players: A retrospective 21-week examination.
PLoS One
August 2024
Integrative and Experimental Training Science, Institute of Sport Sciences, University of Würzburg, Würzburg, Germany.
Objectives: Aims of the present investigation encompassed: (i) the quantification of training and match loads experienced by starters and non-starters within a professional soccer team; (ii) the identification of variations in these loads across different training modalities, namely, Preparation Training (PT), Match and Match Compensation Training (M&MCT), and their cumulative sum (Total Load; TL); and (iii) the formulation of guidelines aimed at harmonizing the weekly workloads between the groups.
Methods: Internal and external load of training sessions (n = 97), competitive matches (n = 21) and running based sessions (n = 4) were recorded for 21 weeks to investigate possible heterogeneity between starters and non-starters across PT, M&MCT and TL.
Results: During PT, time spent in heart rate zone 5 (HRZ5) was increased for non-starters (+46.
Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders.
Sci Rep
August 2024
The Endocrine Program, Department of Animal Sciences, Rutgers, The State University of New Jersey, 67 Poultry Farm Lane, New Brunswick, NJ, USA.
Prenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability. Despite the strong connection between sleep patterns and circadian rhythmicity, relatively little is known about circadian rhythm disruptions in individuals with AE. Recently, several reports demonstrated that evaluating the expression patterns of human clock genes in biological fluids could reveal an individual's circadian phenotype.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!