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Effect of High Temperature Exposure and Laboratory Processing Techniques on the Diagnostic Performance of Dry Swabs for the Detection of African Swine Fever Virus.
Viruses
November 2024
CSIRO, Australian Centre for Disease Preparedness (ACDP), Geelong, VIC 3220, Australia.
One of the key surveillance strategies for the early detection of an African swine fever (ASF) incursion into a country is the sampling of wild or feral pig populations. In Australia, the remote northern regions are considered a risk pathway for ASF incursion due to the combination of high numbers of feral pigs and their close proximity to countries where ASF is present. These regions primarily consist of isolated arid rangelands with high average environmental temperatures.
View Article and Find Full Text PDFStakeholder Consultation Workshop on the Perceived Value of Thermostable Vaccines to Relieve Program Barriers: A Case Study from Côte d'Ivoire.
Vaccines (Basel)
December 2024
PATH-Headquarters, Seattle, WA 98121, USA.
Background: Persistent inequities in access to vaccinations pose challenges for immunization programs worldwide. Innovations facilitating vaccine delivery, such as leveraging vaccine thermostability through a Controlled Temperature Chain (CTC), have emerged as a potential solution to increase coverage in low- and middle-income countries (LMICs) countries such as Côte d'Ivoire, reducing dependence on the cold chain and improving vaccine delivery efficiency. However, the added value of thermostable vaccines and their integration into national immunization programs is under-recognized by stakeholders.
View Article and Find Full Text PDFA Miniaturized and Ultra-Low-Power Wireless Multi-Parameter Monitoring System with Self-Powered Ability for Aircraft Smart Skin.
Sensors (Basel)
December 2024
Research Center of Structural Health Monitoring and Prognosis, State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
The aircraft smart skin (ASS) with structural health monitoring capabilities is a promising technology. It enables the real-time acquisition of the aircraft's structural health status and service environment, thereby improving the performance of the aircraft and ensuring the safety of its operation, which in turn reduces maintenance costs. In this paper, a miniaturized and ultra-low-power wireless multi-parameter monitoring system (WMPMS) for ASS is developed, which is capable of monitoring multiple parameters of an aircraft, including random impact events, vibration, temperature, humidity, and air pressure.
View Article and Find Full Text PDFDevelopment and Evaluation of Five-in-One Vaccine Microneedle Array Patch for Diphtheria, Tetanus, Pertussis, Hepatitis B, and Type b: Immunological Efficacy and Long-Term Stability.
Pharmaceutics
December 2024
Department of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.
: The development of a five-in-one vaccine microneedle patch (five-in-one MN patch) aims to address challenges in administering vaccines against Diphtheria (DT), Tetanus (TT), Pertussis (wP), Hepatitis B (HBsAg), and type b (Hib). Combining multiple vaccines into a single patch offers a novel solution to improve vaccine accessibility, stability, and delivery efficiency, particularly in resource-limited settings. : The five-in-one MN patch consists of four distinct microneedle arrays: DT and TT vaccines are coated together on one array, while wP, HepB, and Hib vaccines are coated separately on individual arrays.
View Article and Find Full Text PDFEffects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media.
Pharmaceutics
December 2024
University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Background/objectives: Clofazimine (CFZ) is a Biopharmaceutics Classification System (BCS) II drug introduced in the US market in 1986 for the treatment of leprosy. However, CFZ was later withdrawn from the market due to its extremely low aqueous solubility and low absorption. In the literature, the intrinsic solubility of CFZ has been estimated to be <0.
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