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Pediatric Mycosis Fungoides Mimicking Benign Dermatoses: A Report of a Rare Case.
Am J Case Rep
January 2025
Department of Pathology, Hospital Selayang, Batu Caves, Selangor, Malaysia.
BACKGROUND Primary cutaneous lymphomas (PCL) are a multifaceted spectrum of cutaneous T cell lymphoma (CTCL) and cutaneous B cell lymphomas (CBCL). Mycosis fungoides (MF) is a rare subset of CTCL that primarily affects adults, and its occurrence in children is exceedingly rare. Most pediatric MF manifests as hypopigmented patches resembling other benign dermatoses, causing diagnostic challenges.
View Article and Find Full Text PDFA Gastrointestinal Manifestation of Primary Cutaneous Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma: A Case Report.
Cureus
October 2024
Gastroenterology, Hackensack Meridian Health, Palisades Medical Center, North Bergen, USA.
Article Synopsis
- Cutaneous T-cell lymphomas (CTCL) are the most common type of primary skin lymphoma, primarily affecting the skin but also showing extracutaneous symptoms.
- Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECTCL) is a rare, aggressive subtype with poor outcomes and potential for systemic spread, particularly to organs like the lungs and central nervous system.
- A case study is presented of a patient with a persistent rash diagnosed with pcAECTCL, where imaging showed possible gastric involvement, but no definitive evidence of metastasis was found after further examination.
Unveiling the Rarity: CD20 Expression in Mycosis Fungoides and Its Clinical Significance.
Am J Dermatopathol
October 2024
Department of Pathology and Dermatology, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston-Salem, NC.
Article Synopsis
- CD20 expression is rare in mycosis fungoides (MF) but has been documented in isolated cases, highlighting a unique instance in a 30-year-old man with a specific skin manifestation.
- Histopathological analysis revealed neoplastic T cells displaying markers typical of MF, with a subset also expressing CD20, indicating potential implications for diagnosis and treatment.
- The clinical significance of CD20 positivity in MF is unclear, raising questions about immune dysregulation and disease progression, emphasizing the need for more research to understand its impact on prognosis and treatment strategies.
Navigating Diagnostic and Therapeutic Challenges in Primary Cutaneous Gamma/Delta T-Cell Lymphoma: A Case Study of Fatal Outcomes Within Two Months.
Am J Dermatopathol
September 2024
Department of Pathology and Dermatology, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston-Salem, NC; and.
Primary cutaneous gamma/delta T-cell lymphoma (PCGD-TCL) is a rare yet highly aggressive subtype of primary cutaneous lymphoma. Characterized by its challenging diagnosis and poor prognosis, PCGD-TCL presents unique clinical and histopathological features that distinguish it from other primary cutaneous lymphoma subtypes. Here, we report the case of a 75-year-old man who initially presented with multiple erythematous indurated plaques over his back and bilateral lower extremities.
View Article and Find Full Text PDFChronic Radiation Dermatitis Secondary to Narrow-Band Ultraviolet B Therapy in a Patient With Primary Cutaneous CD8 + T-Cell Lymphoma With Cytotoxic Granules.
Am J Dermatopathol
May 2024
Division of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA.
Conventional therapies for CD8 + cutaneous T-cell lymphoma include topical steroids, topical nitrogen mustard, topical bexarotene, ultraviolet B therapy, psoralen and ultraviolet A therapy, local radiotherapy, and interferon alfa; however, these treatments are often found to be ineffective. Presented is a case of CD8 + cutaneous T-cell lymphoma with near-complete response to narrow-band ultraviolet therapy because of chronic radiation dermatitis initially believed to be possible progression of a CD8 + cutaneous epidermotropic cytotoxic T-cell lymphoma.
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