AI Article Synopsis

  • The text discusses how cellular differentiation relies on carefully regulated gene expression that varies by tissue type and developmental stage.
  • It highlights the role of enhancers in determining lineage-specific gene expression and reviews their behavior during the process of hematopoietic differentiation, including the 3D structure of the genome.
  • The piece also touches on how faulty enhancer activity can lead to human diseases and explores new strategies to manage enhancer function and chromosome organization for potential therapies.

Article Abstract

Cellular differentiation requires precisely regulated tissue-specific and developmental stage-specific gene expression patterns. Numerous studies have highlighted the predictive power of enhancers on lineage-specific gene expression programs and have started to unravel their mechanisms of action. We review here the dynamics of the enhancer landscape during hematopoietic differentiation and how enhancers function in the context of the 3D organization of the genome. We further discuss the involvement of aberrant enhancer activity in human diseases and emerging strategies aiming at controlling enhancer activity and chromosome topology for therapeutic purposes.

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Source
http://dx.doi.org/10.1002/1873-3468.12424DOI Listing

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