Maltreatment-related childhood adversity is the leading preventable risk factor for mental illness and substance abuse. Although the association between maltreatment and psychopathology is compelling, there is a pressing need to understand how maltreatment increases the risk of psychiatric disorders. Emerging evidence suggests that maltreatment alters trajectories of brain development to affect sensory systems, network architecture and circuits involved in threat detection, emotional regulation and reward anticipation. This Review explores whether these alterations reflect toxic effects of early-life stress or potentially adaptive modifications, the relationship between psychopathology and brain changes, and the distinction between resilience, susceptibility and compensation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nrn.2016.111 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Childhood and Adolescent Overweight/Obesity Prevalence Trends in Jiangsu, China, 2017-2021: An Age-Period-Cohort Analysis.
Public Health Nurs
December 2024
Department of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Objectives: To investigate temporal trends in childhood and adolescent overweight/obesity in Jiangsu Province, China, evaluating the effects of age, period, and birth cohort.
Design: Cross-sectional study.
Sample: Participants were 210,168 students aged 6-17 years from the five waves of the consecutive cross-sectional Jiangsu provincial surveillance project in 2017-2021.
Neuroblastoma Occurring in Nijmegen Breakage Syndrome.
J Pediatr Hematol Oncol
January 2025
Medical Faculty, University of Belgrade.
Nijmegen breakage syndrome (NBS) is a rare primary immunodeficiency disease due to a pathogenic variant in the NBN gene causing impaired DNA repair and increased predisposition for lymphoid malignancy. By contrast, solid tumors have been rarely reported. Neuroblastoma (NB) is a rare childhood solid tumor, associated with the worse outcome if MYCN oncogene is amplified.
View Article and Find Full Text PDFA systematic review of predictors and moderators of treatment response in psychological interventions for persisting forms of depression.
Br J Clin Psychol
December 2024
Clinical and Applied Psychology Unit, School of Psychology, University of Sheffield, Sheffield, UK.
Background: Although psychological interventions can be effective for the treatment of major depressive disorder, some patients' symptoms persist or rapidly recur after therapy. This study aimed to synthesize research findings on predictors and moderators of treatment response for persisting forms of depression, such as chronic, recurrent, and treatment-resistant depression.
Methods: A systematic review of studies investigating predictors and moderators of response to outpatient psychological treatment for adults with persisting forms of depression was conducted by searching Web of Science, Scopus, and PsycInfo.
Using therapeutic letters in group schematherapy.
Neuro Endocrinol Lett
December 2024
Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic.
Objective: This article focuses on utilizing therapeutic letters within group schema therapy-an innovative therapeutic approach that integrates elements from various therapeutic disciplines. The primary aim is to explore how therapeutic letters can enhance the therapeutic process and support the treatment of patients.
Methods: To achieve this objective, we conducted a narrative literature review centred on schema therapy and using therapeutic letters as a therapeutic strategy.
School-based adolescent health survey in Himachal Pradesh, India: study design and protocol.
Front Public Health
December 2024
Mamta Health Institute for Mother and Child (HIMC), New Delhi, India.
Background: The World Health Organization defined adolescent age group as a life span between 10 and 19 years. Adolescence is a phase of transition from childhood to adulthood, it is a unique stage for human development and a very sensitive period for laying the foundation of good health. Investment in this life-stage yields triple dividend.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!