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Background: Neurolymphomatosis is a lymphoid malignancy of the peripheral nervous system and its natural history is poorly understood.

Methods: We performed PubMed search and extracted clinical data for Kaplan-Meier statistics to determine outcome parameters over time. Kruskal-Wallis test was performed to compare prognostic factors.

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Article Synopsis
  • Neurolymphomatosis (NL) is a rare condition where lymphoma cells invade the peripheral nervous system, and its treatment options and prognosis are not well-defined.
  • This study investigates predictive factors for secondary NL, revealing common chromosomal abnormalities, like deletions on chromosome 10, which may aid in early detection.
  • When patients with diffuse large B-cell lymphoma show neurological symptoms and chromosomal abnormalities, there’s a potential risk for developing secondary NL that should be evaluated.
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Toxicities and outcome after CD19-directed chimeric antigen receptor T-cell therapy for secondary neurolymphomatosis.

Am J Hematol

December 2024

Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

Lymphomatous infiltration of the peripheral nervous system (PNS), termed neurolymphomatosis, represents a distinct extranodal non-Hodgkin lymphoma variant with dismal outcome. CD19-directed chimeric antigen receptor (CD19-CAR) T-cell therapy has emerged as a safe and effective treatment for B-cell lymphomas. We aimed to assess toxicity and efficacy of CD19-CAR T-cells in neurolymphomatosis.

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