AI Article Synopsis
- The study aimed to compare the effectiveness of different lidocaine doses for reducing pain during prostate biopsies guided by transrectal ultrasound (TRUS).
- A total of 288 patients were divided into three groups, receiving either a gel or various volumes of injected lidocaine, with their pain assessed using a visual analogue scale (VAS).
- Results indicated that the group receiving the highest injection dose (4 mL) reported significantly lower pain compared to the other groups, suggesting this method may be more effective, though further research is needed for confirmation.
Article Abstract
Objective: To compare two different doses of lidocaine used for periprostatic nerve block on pain perception during transrectal ultrasound (TRUS) guided prostate biopsy.
Material And Methods: A total of 288 patients with elevated prostate specific antigen (PSA) levels and/or abnormal digital rectal examination who underwent TRUS-guided prostate biopsy were included in the study. The patients were divided into 3 groups: Group 1 (n=103) prostate biopsy were performed after administering perianal intrarectal application of 10 mL 2% lidocaine gel, Group 2 (n=98) 2 mL of 2% lidocaine injection on each side following rectal installation of lidocaine gel and Group 3 (n=87) 4 mL of 2% lidocaine injection on each side after rectal instillation of lidocaine gel. Patients' pain scores during biopsy procedure were reported using visual analogue score (VAS). Independent sample t test, ANOVA test and Tukey test were used for statistical evaluation.
Results: The mean age, prostate volume and PSA level were 65.6±8.4 years, 58.2±34.8 mL, and 11.8±3.4 ng/mL respectively. There were no statistically significant differences in baseline characteristics between the groups. The mean VAS scores were 2.4±1.8 in Group 1, 2.5±1.9 in Group 2 and 1.6±1.6 in Group 3. Patients in Group 3, reported significant pain reduction compared with patients in Groups 1 and 2 (p=0.002, and 0.001, respectively). However, there was no statistically significant difference in VAS scores between Groups 1 and 2 (p=0.815).
Conclusion: According to our results we recommend the use of perianal intrarectal lidocain gel application, and periprostatic nerve block with injection of 4 ml 2% lidocaine per side combination in TRUS-guided prostate biopsies. Further large-scale randomized control studies are needed to validate these finding.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012440 | PMC |
| http://dx.doi.org/10.5152/tud.2016.38107 | DOI Listing |
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