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Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics. | LitMetric

AI Article Synopsis

Article Abstract

Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ∼130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions. We discuss mechanisms that potentially explain these observations, and their implications for understanding the association of EBV with human disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203774PMC
http://dx.doi.org/10.1093/gbe/evw226DOI Listing

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