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Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. | LitMetric

AI Article Synopsis

  • Identifying reliable markers for chemotherapy and radiotherapy effectiveness in head and neck squamous cell carcinoma (HNSCC) is crucial, with the regenerating gene (REG) III linked to better survival outcomes for patients.
  • The study examined various substances to induce REG III expression, finding that resveratrol notably enhanced REG III activity in HNSCC cells.
  • Resveratrol was shown to significantly slow down cancer cell growth, improve sensitivity to chemotherapy and radiation, and reduce cancer invasion, indicating its potential in hindering cancer progression through the REG III pathway.

Article Abstract

Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.

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Source
http://dx.doi.org/10.3892/ijo.2016.3664DOI Listing

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