Purpose: To find the real relationship between maternal total homocysteine (tHcy) level and risk of neural tube defects (NTDs).
Materials And Methods: A systematic review and meta-analysis were conducted. The literature search was conducted with the use of PubMed and EMBASE databases and weighted mean difference (WMD) with 95% confidence interval (CI) was applied to measure the difference in tHcy level between case and control group. Seventeen articles involving 3237 subjects were included according to the inclusion criteria.
Results: Pooled result showed that mothers with NTDs offspring demonstrated significantly a higher mean log plasma tHcy level than mothers with normal offspring (log WMD: 0.06; 95%CI: 0.02-0.09, p = 0.001), corresponding to an increase of 6% (2-9%) in the geometric mean. Subgroup analyses also displayed this difference in subjects who were detected during pregnancy or without folate supplementation before sampling. However, in the mandatory folate fortification countries, we did not find this association.
Conclusions: A slightly higher tHcy level in mothers with NTDs was indicated, but potential confounders could not be ruled out completely. Further larger or cohort studies are needed to confirm this association.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14767058.2016.1236248 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High clinical burden of classical homocystinuria in the United States: a retrospective analysis.
Orphanet J Rare Dis
January 2025
Travere Therapeutics, Inc., San Diego, CA, USA.
Background: Classical homocystinuria (HCU) is a rare genetic metabolic disorder resulting in elevated homocysteine and methionine levels. The clinical characteristics and associated complications of HCU are well documented. However, there is limited published research on the clinical burden of patients with HCU, especially stratified by total homocysteine (tHcy) levels.
View Article and Find Full Text PDFImpaired folate status in patients with mental disorders.
Acta Neuropsychiatr
January 2025
Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Objective: Folate and cobalamin deficiency or impaired function due to genetic variants in key enzymes, have been associated with neuropsychiatric symptoms. The aim of this study was to compare folate and cobalamin status in patients admitted to an acute psychiatric unit to patients from primary health care, in order to reveal factors which may be important in the follow-up of patents with mental disorders.
Methods: Anonymous blood samples tested for folate, cobalamin, the metabolic marker total homocysteine (tHcy), creatinine and glomerular filtration rate, as well as age and gender in patients admitted to a psychiatric acute unit (n=981) and patients from primary health care (controls) (n=32201) were reviewed retrospectively.
Lipoprotein(a), high-sensitivity c-reactive protein, homocysteine and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.
Am J Prev Cardiol
March 2025
Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Background And Aims: Elevated lipoprotein(a) [Lp(a)], high-sensitivity C-Reactive Protein (hs-CRP), and total homocysteine (tHcy) are associated with atherosclerotic cardiovascular disease (ASCVD) risk. This study investigated the individual and joint associations of Lp(a), hs-CRP and tHcy with coronary heart disease (CHD) and stroke.
Methods: This study was conducted in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (2000-2017) (CHD analytic = 6,676; stroke analytic = 6,674 men and women).
Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations.
Neurology
February 2025
Department of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Background And Objectives: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme that regulates folate and homocysteine metabolism. Genetic variation in has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking. We thus aimed to investigate the effect of genetically predicted MTHFR activity on risk of ischemic stroke (IS) and its main subtypes using a multiancestry Mendelian randomization (MR) approach.
View Article and Find Full Text PDFElevated plasma total homocysteine levels are associated with behavioral and psychological symptoms in dementia with Lewy bodies.
Front Neurosci
November 2024
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- This study aimed to explore the link between plasma total homocysteine (tHcy) levels and behavioral and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies (DLB).
- Among 82 DLB patients, a significant 92.7% exhibited clinically significant BPSD, with hallucinations and apathy being the most common symptoms; elevated tHcy levels were notably associated with higher NPI scores in DLB patients.
- The findings suggest that controlling homocysteine levels might provide a new approach for managing BPSD in DLB, although further research with larger groups is needed to confirm these results.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!