A total of 206 patients with acute myocardial infarction marked by infarction localization in the anterior and inferior walls were examined. It is revealed that reciprocal changes, namely the depression of the ST segment are of prognostic significance in the assessment of the clinical course of the disease, with the ST depression being recorded for over one day. The patients demonstrated a reduction in left ventricle (LV) function, namely a decrease in the ejection fraction of the LV. Moreover, in this group of patients, a greater number of cases with multiple lesions of the coronary vessels were recorded. The reciprocal changes correlated well with the size of myocardial injury.
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J Pers
January 2025
Self and Identity Development Laboratory, Department of Psychology, Babes-Bolyai University, Cluj-Napoca, Romania.
Introduction: Previous studies have revealed that perfectionism and identity development during adolescence are related. However, no longitudinal study has been conducted on the impact of perfectionism on identity development in adulthood. In the present study, we analyzed for the first time the longitudinal relationship between personal standards, an indicator of perfectionistic strivings, and concern over mistakes and doubts about actions, indicators of perfectionist concerns, and identity development in one of the most important yet least understood domains for adults, parental identity.
View Article and Find Full Text PDFHum Mol Genet
January 2025
Department of Human Genetics, McGill University, 3666 McTavish Street, Montreal, QC H3A 1Y2, Canada.
Many genes in the human genome encode proteins that are dosage sensitive, meaning they require protein levels within a narrow range to properly execute function. To investigate if clinically relevant variation in protein levels impacts the same downstream pathways in human disease, we generated cell models of two SETBP1 syndromes: Schinzel-Giedion Syndrome (SGS) and SETBP1 haploinsufficiency disease (SHD), where SGS is caused by too much protein, and SHD is caused by not enough SETBP1. Using patient and sex-matched healthy first-degree relatives from both SGS and SHD SETBP1 cases, we assessed how SETBP1 protein dosage affects downstream pathways in human forebrain progenitor cells.
View Article and Find Full Text PDFMol Cell
January 2025
Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain; Departamento de Genética, Universidad de Sevilla, 41012 Seville, Spain. Electronic address:
Significant effort has been spent attempting to unravel the causal relationship between histone post-translational modifications and fundamental DNA processes, including transcription, replication, and repair. However, less attention has been paid to understanding the reciprocal influence-that is, how DNA processes, in turn, shape the distribution and patterns of histone modifications and how these changes convey information, both temporally and spatially, from one process to another. Here, we review how histone modifications underpin the widespread bidirectional crosstalk between different DNA processes, which allow seemingly distinct phenomena to operate as a unified whole.
View Article and Find Full Text PDFConserv Biol
January 2025
Humanities and Social Sciences Department, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, India.
Indigenous ecological knowledge (IEK) has proven effective in environmental governance, forest management, and sustainable development, yet it is threatened by globalization and rapid social-ecological changes. In southern India, I investigated the engagement of the Kattunaicken community with the forest, particularly through honey collection, to explore the connection between their Indigenous epistemological identity and their role in caring for the forest and its inhabitants. I conducted 48 interviews and accompanied 11 forest walks as part of walking ethnography with male community members, who are primarily involved in honey collection within the Wayanad district of Kerala.
View Article and Find Full Text PDFDev Psychol
January 2025
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill.
This study examined reciprocal relations between two dimensions of peer status, likability and popularity, and two dimensions of empathy, empathic concern and perspective taking, across adolescence. A school-based sample of 893 ( = 12.60, = 0.
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