Fifty-five patients with "pure" aortal failure (AF) aged 16 to 48 years were examined. There were 39 men and 16 women. Of these, 22 patients presented with minimal, 20 with moderate, and 13 with pronounced AF. The protodiastolic murmur regarded as the most significant clinical sign could be heard in 19 out of the 22 patients with minimal AF, which appears to be determined by high frequency oscillations connected with the protodiastolic murmur. During phonocardiographic studies, that murmur was recorded only in 8 patients (36.6 percent) with minimal AF. Analysis of the ECG readings identified the signs of insignificant hypertrophy of the left ventricle (LV) only in 5 out of the 22 patients. The employment of Doppler's ultrasound cardiography made it possible to record the reverse blood flow in the left ventricle cavity in all the cases. In patients with minimal AF, the ultrasound cardiography did not discover any enlargement of the size, thickness of the walls or mass of the LV myocardium. Myocardial contractility, the stroke and cardiac indices remained within normal. However, there was a decrease in the effective ejection fraction of the LV. The typical "vibration" of the anterior cusp of the mitral valve was demonstrable in all AF patients. Thus the clinical and instrumental examination of patients with minimal AF permitted revealing the definite diagnostic characteristics which should be taken into consideration to recognize the heart disease under discussion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial.
J Clin Psychiatry
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.
To provide proof-of-concept (PoC), dose-range finding, and safety data for BI 1358894, a TRPC4/5 ion channel inhibitor, in patients with borderline personality disorder (BPD). This was a phase 2, multinational, randomized, double-blind, placebo controlled trial. Patients were randomized to oral placebo or BI 1358894 (5 mg, 25 mg, 75 mg, or 125 mg) once daily in a 2.
View Article and Find Full Text PDFCoexisting sellar Rathke cleft cyst and planum sphenoidale meningioma: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Background: The co-occurrence of Rathke cleft cysts (RCCs) and meningiomas in the sellar and parasellar regions represents an exceedingly rare clinical entity. Achieving maximal resection through a single operative approach while minimizing adverse events is challenging, often necessitating multiple surgical approaches, as suggested by previous reports.
Observations: The authors report the case of a 49-year-old female with a history of kidney transplant who presented with headaches and was diagnosed with coexisting RCC and meningioma in the sellar and planum sphenoidale regions, respectively.
Guidelines for Patient-Centered Documentation in the Era of Open Notes: Qualitative Study.
JMIR Med Educ
January 2025
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Background: Patients in the United States have recently gained federally mandated, free, and ready electronic access to clinicians' computerized notes in their medical records ("open notes"). This change from longstanding practice can benefit patients in clinically important ways, but studies show some patients feel judged or stigmatized by words or phrases embedded in their records. Therefore, it is imperative that clinicians adopt documentation techniques that help both to empower patients and minimize potential harms.
View Article and Find Full Text PDFThe Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach.
Brain Behav
January 2025
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Introduction: Patients with bipolar disorder (BD) demonstrate episodic memory deficits, which may be hippocampal-dependent and may be attenuated in lithium responders. Induced pluripotent stem cell-derived CA3 pyramidal cell-like neurons show significant hyperexcitability in lithium-responsive BD patients, while lithium nonresponders show marked variance in hyperexcitability. We hypothesize that this variable excitability will impair episodic memory recall, as assessed by cued retrieval (pattern completion) within a computational model of the hippocampal CA3.
View Article and Find Full Text PDFRadiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease?
Oncologist
January 2025
Department of Orthopaedic Surgery, Division of Surgical Specialties, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
This narrative review provides a comprehensive overview of the current status, recent advancements, and future directions in the management of metastatic spine disease using both radiotherapy and surgery. Emphasis has been put on the integrated use of radiotherapy and surgery, incorporating recent developments such as separation surgery, active dose sparing of the surgical field, and the implementation of carbon fiber-reinforced polymer implants. Future studies should explore the effects of minimizing the time between radiotherapy and surgery and investigate the potential of vertebral re-ossification after radiotherapy to obviate the need for stabilization surgery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!