AI Article Synopsis
- HNSCC is the sixth most common cancer globally, but current treatment methods aren't highly effective, leading researchers to explore better detection techniques.
- The study involved 72 patients and used oral brush biopsies and GLUT-1 staining to identify premalignant and malignant lesions, comparing results against incisional biopsies as the gold standard.
- The findings showed 80% sensitivity and 68.42% specificity for detecting cancer, suggesting that while oral brush biopsies are noninvasive and useful, GLUT-1 staining alone may not fully suffice for detecting malignant changes but can be a helpful supplementary method.
Article Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common tumor entity worldwide. Unfortunately, the multimodal treatment consisting of surgery, radiation, and chemotherapy does not show the desired efficacy. The intent of this study was to evaluate the sensitivity and specificity of an oral brush biopsy in combination with glucose transporter (GLUT)-1 staining in identifying premalignant and malignant lesions.
Methods: A total of 72 patients were included in the study, divided into four diagnostic subgroups (24 healthy, 15 carcinoma, 18 leukoplakia, 15 oral lichen planus). Oral brush biopsies were taken and analyzed for GLUT-1 expression by immunocytologic staining. Incisional biopsy served as the gold standard.
Results: Twelve (80 %) of the 15 carcinomas, nine (50 %) of the 18 leukoplakia, nine (60 %) of the 15 oral lichen planus, and none of the healthy specimens stained positive for GLUT-1. This resulted in a sensitivity rate of 80 % and a specificity rate of 68.42 %. Diagnostic accuracy was 70.83 % based on the correct diagnoses in 51 of 72 patients.
Conclusion: An oral brush biopsy can easily be performed throughout the entire oral cavity, is noninvasive, and shows high sensitivity and specificity rates with conventional cytology or computer-assisted analysis.
Clinical Relevance: The significance of GLUT-1-specific staining with an oral brush biopsy is more limited than expected but could be used as an additional tool in detecting malignant transformation in the oral cavity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00784-016-1954-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of oral health promotion in children and adolescents through behaviour change interventions: A scoping review.
PLoS One
January 2025
Department of Prosthodontics, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
Objective: To explore the interventions for change in oral health behaviour that are effective in improving oral health behaviours in 8 to 18-year-old children during oral health promotion.
Methods: The Joanna Briggs Institute framework of evidence synthesis for conducting a scoping review was implemented for the methodology. Included studies related to the objective, measured clinical or non-clinical outcomes, were in English, 2011-2023, and were experimental, observational or reviews.
Comparative Evaluation of Two Novel Natural Desensitizing Agents on Dentinal Tubule Occlusion: A Scanning Electron Microscopy Study.
J Contemp Dent Pract
September 2024
Department of Conservative Dentistry and Endodontics, PMNM Dental College and Hospital, Bagalkot, Karnataka, India.
Aim: The present study is aimed to compare the effectiveness of dentinal tubule occlusion of two natural-based desensitizing toothpaste (Bentodent Desensitizer and Fang Farm Mint) and Novamin-based toothpaste (Shy-NM) under scanning electron microscope (SEM).
Materials And Methods: A total of 60 root dentin discs (3 mm-thick) were obtained from recently extracted permanent premolar teeth and were randomly divided into four groups based on the desensitizing toothpaste used, each group with 15 samples: Group I: Control, group II: Shy-NM, group III: Bentodent desensitizer, group IV: Fang Farm Mint. Samples were brushed for 2 min twice daily with a soft toothbrush with respective pea size amount of toothpaste for 14 days manually.
Effectiveness of Braille and ATP Technique in Improving Oral Hygiene Status of Visually Impaired Children: An Interventional Study.
J Contemp Dent Pract
September 2024
Department of Public Health Dentistry, MES Dental College and Hospital, Malappuram, Kerala, India.
Aim: The study aimed to subject two groups of visually challenged children to Braille and audio-tactile performance (ATP) techniques of oral health education and compare the effectiveness of each technique through a comparison of OHI-S index scores.
Materials And Methods: 30 visually challenged children of 6-12 years belonging to a Government-aided blind school were divided into two study groups based on the method of oral health education ( = 15). Group I received oral hygiene instructions in Braille while group II received instructions through audio clips, tactile sensations of tooth models, and closely supervised performance of brushing technique.
Implementation of a program to strengthen oral hygiene in patient with cleft deformities: a prospective randomized controlled clinical trial.
Trials
January 2025
INSERM, Regenerative Medicine and Skeleton, RMeS, CHU Nantes, Nantes Université, UMR 1229, Nantes, 44000, France.
Background: Cleft lip and/or palate is the most common congenital orofacial deformity, affecting 1/800 births. A thorough review of the literature has shown that children with cleft have poorer oral hygiene and dental health than other children, with higher levels of caries in both temporary and permanent teeth and poorer periodontal health. Cleft patients are treated by a multidisciplinary team that aims to provide comprehensive care from pre- or post-natal diagnosis to early adulthood and the end of growth.
View Article and Find Full Text PDFInvited review: Social housing of dairy calves: management factors affecting calf behavior, performance, and health - A systematic review.
J Dairy Sci
January 2025
Department of Animal and Veterinary Sciences, Aarhus University, Tjele, Denmark.
Given increasing adoption of social housing for pre-weaned dairy calves, we conducted a systematic review to summarize existing literature describing effects of social housing management factors on behavior, performance, and health of dairy calves. Included articles addressed interventions applied to pre-weaned, socially housed dairy calves, encompassing age at introduction to social housing, group composition (size, stocking density, within-group age range, stability), and housing environment (space allowance, enrichment provision). Outcome measures addressed behavior, including social behavior, locomotor behavior, feeding behavior, abnormal oral behavior, and behavioral responses during tests; performance, including body measurements and weight gain; and health, including clinical health scores and mortality rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!